Stable recombinant adenosine deaminase
AssigneeDefiante Farmaceutica, S.A.
InventorsDavid R. Filpula, Stephen K. Youngster
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Abstract
A mutein recombinant adenosine deaminase having any oxidizable cysteine residue replaced by a non-oxidizable amino acid residue is disclosed. Stabilized recombinant adenosine deaminase, polymer conjugates and methods of treatment using the same are also disclosed.
Claims19
An isolated recombinant adenosine deaminase comprising the polypeptide of SEQ ID NO:1, or an isolated recombinant adenosine deaminase variant polypeptide of SEQ ID NO:1, wherein the polypeptide variant of SEQ ID NO:1 comprises one or more amino acid substitutions selected from the group consisting of:
- Gin in place of Lys198;
- Ala in place of Thr245;
- and Arg in place of Gly351.
An isolated DNA that encodes a recombinant adenosine deaminase having the amino acid sequence comprising SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.