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US 8,071,643 B2Granted
Pleuromutilin derivatives for the treatment of diseases mediated by microbes
AssigneeNabriva Therapeutics AG
InventorsRosemarie Mang, Werner Heilmayer, Rudolf Badegruber, Dirk B. Strickmann, Rodger Novak, Mathias Ferencic, Atchyuta Rama Chandra Murty Bulusu
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Abstract
A pleuromutilin derivative compound of general formula (I)
Claims11
A compound of formula (I)
- wherein
- n is 0 to 4;
- m is 0 or 1 with the proviso that the sulphur atom and R3 are in vicinal position, if m =0 then R3 is in position 2′, and if m =1 then R3 is on position 1′;
- R is ethyl or vinyl;
- R1 is hydrogen or (C1-6)alkyl,
- R2 is hydrogen or
- (C3-6)cycloalkyl, or
- unsubstituted (C1-6)alkyl, or
- (C1-6)alkyl substituted by one or more of
- hydroxy,
- methoxy,
- halogen, or
- (C3-6)cycloalkyl, or
- R1 and R2 together with the nitrogen atom to which they are attached form a 5 to 7 membered heterocyclic ring containing at least 1 nitrogen atom or 1 nitrogen and 1 additional heteroatom selected from N or O, or
- R1 is hydroxy and R2 is formyl;
- R3 is OH, OR4, or a halogen atom, or
- R3 is bound to 2′ and R3 represents —O—(CH2)p—O— with p being 2 or 3;
- and
- R4 is unsubstituted (C1-6)alkyl or (C3-6)cycloalkyl.
16 more elements
Dependencies are inferred from the claim text.