Virus derived antimicrobial peptides
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsRonald C. Montelaro, Timothy A. Mietzner
Life of this patent
Estimating the term…
Loading patent…
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsRonald C. Montelaro, Timothy A. Mietzner
Estimating the term…
Described herein are peptides having antimicrobial activity (antimicrobial peptides). The antimicrobial peptides, designated LBU, WLBU and WR, are analogs of the Lentivirus Lytic Peptide 1 (LLP1) amino acid sequence. The antimicrobial peptides are monomers or multimers of peptides referred to as the Lytic Base Unit (LBU) peptides, derived from the LLP1 analogs and also having antimicrobial activity. Also described herein are using the peptides in a variety of contexts, including the treatment or prevention of infectious diseases. Methods of killing fungi, such as Candida and Cryptococcus species, and bacteria, such as B. anthracis, are provided herein. Methods of neutralizing enveloped viruses, such as poxvirus, herpesvirus, rhabdovirus, hepadnavirus, baculovirus, orthomyxovirus, paramyxovirus, retrovirus, togavirus, bunyavirus and flavivirus, including influenza virus and HIV-1 also are provided herein. Solid phase substrates and peptide-cargo complexes comprising the peptides also are provided.
An isolated and purified peptide having an amino acid sequence selected from the group consisting of:
A method of neutralizing an enveloped virus, comprising contacting the virus with one or more antimicrobial peptides chosen from WR12 (SEQ ID NO:
A method of neutralizing an orthomyxovirus, comprising contacting the virus with one or more antimicrobial peptides chosen from WR12 (SEQ ID NO:
A method of killing a Bacillus anthracia bacterium, vegetative form, comprising contacting the bacterium with one or more antimicrobial peptides chosen from WR12 (SEQ ID NO:
A method of killing a fungus of the Genera Candida or Cryptococcus, comprising contacting the fungus with one or more antimicrobial peptides chosen from WR12 (SEQ ID NO:
An isolated and purified peptide-cargo complex comprising a cargo and a peptide chosen from WR12 (SEQ ID NO:
A solid phase substrate comprising at least one peptide chosen from:
Dependencies are inferred from the claim text.