Covalent assembly of ultrathin polymeric films
AssigneeWiscousin Alumni Research Foundation
InventorsDavid M. Lynn, Maren E. Buck, Jingtao Zhang
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Abstract
In one aspect, described herein are ultrathin films comprising an azlactone functionalized polymer and a primary amine functionalized polymer. Also described herein are ultrathin films including reactive, nonreactive, partially reactive/nonreactive, hydrophobic, hydrophilic, and mixed hydrophobic/hydrophilic ultrathin films. In another aspect, described herein are methods for making surface attached and freestanding ultrathin films.
Claims78
An ultrathin film comprising an azlactone functionalized first polymer and a second polymer selected from the group consisting of a primary amine functionalized polymer, an alcohol functionalized polymer and a thiol functionalized polymer.
A hydrophilic ultrathin film comprising:
- an azlactone functionalized first polymer;
- a second polymer selected from the group consisting of a primary amine functionalized polymer, an alcohol functionalized polymer and a thiol functionalized polymer;
- and a non-polymeric hydrophilic primary amine;
- wherein a portion of the azlactone functional groups of the azlactone functionalized first polymer are reacted with at least a portion of the primary amine, alcohol, or thiol functional groups of the second polymer and at least a portion of the azlactone functional groups of the azlactone functionalized first polymer are reacted with at least a portion of the non-polymeric hydrophilic primary amine.
A hydrophobic ultrathin film comprising:
- an azlactone functionalized first polymer;
- a second polymer selected from the group consisting of a primary amine functionalized polymer, an alcohol functionalized polymer and a thiol functionalized polymer;
- and a non-polymeric hydrophobic primary amine;
- wherein a portion of the azlactone functional groups of the azlactone functionalized first polymer are reacted with at least a portion of the primary amine, alcohol, or thiol functional groups of the second polymer and at least a portion of the azlactone functional groups of the azlactone functionalized first polymer are reacted with at least a portion of the non-polymeric hydrophobic primary amine.
A mixed hydrophilic-hydrophobic ultrathin film comprising:
- an azlactone functionalized first polymer;
- a second polymer selected from the group consisting of a primary amine functionalized polymer, an alcohol functionalized polymer and a thiol functionalized polymer;
- a non-polymeric hydrophilic primary amine;
- and a non-polymeric hydrophobic amine;
- wherein a portion of the azlactone functional groups of the azlactone functionalized first polymer are reacted with at least a portion of the primary amine, alcohol, or thiol functional groups of the second polymer, at least a portion of the azlactone functional groups of the azlactone functionalized first polymer are reacted with at least a portion of the non-polymeric hydrophilic primary amine and at least a portion of the azlactone functional groups of the azlactone functionalized first polymer are reacted with at least a portion of the non-polymeric hydrophobic primary amine.
A method of making an ultrathin film, the method comprising the steps of:
- a. exposing a surface to a first solution comprising a first polymer selected from the group consisting of a primary amine functionalized polymer, an alcohol functionalized polymer and a thiol functionalized polymer;
- and
- b. exposing the surface to a second solution comprising an azlactone functionalized second polymer.
A method for preventing cell or protein adhesion to a surface, the method comprising the steps of:
- a. exposing a surface to a first solution comprising a first polymer selected from the group consisting of a primary amine functionalized polymer, an alcohol functionalized polymer and a thiol functionalized polymer;
- and
- b. exposing the surface to a second solution comprising an azlactone functionalized second polymer;
- and
- c. exposing the surface to a third solution comprising a non-polymeric hydrophilic primary amine.
A method for promoting cell or protein adhesion to a surface, the method comprising the steps of:
- a. exposing a surface to a first solution comprising a first polymer selected from the group consisting of a primary amine functionalized polymer, an alcohol functionalized polymer and a thiol functionalized polymer;
- and
- b. exposing the surface to a second solution comprising an azlactone functionalized second polymer;
- and
- c. exposing the surface to a cell or protein.
Dependencies are inferred from the claim text.