Process for preparing aminocrotonylamino-substituted quinazoline derivatives
AssigneeBoehringer Ingelheim International GmbH
InventorsJuergen Schroeder, Georg Dziewas
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Abstract
The invention relates to an improved process for preparing aminocrotonylamino-substituted quinazoline derivatives of general formula (I) wherein the groups Ra, Rb, Rc and Rd have the meanings given in the claims, as well as sulphonyl derivatives of formula and the use thereof as synthesis components for preparing quinazolines of formula (I). The quinazoline derivatives of formula (I) are inhibitors of signal transduction mediated by tyrosinekinases and by the Epidermal Growth Factor-Receptor (EGF-R) and are therefore particularly suitable for the treatment of tumoral diseases.
Claims4
A compound of the formula
- wherein
- Ra denotes a benzyl, 1-phenylethyl or 3-chloro-4-fluorophenyl group and
- R3 denotes a C1-4-alkyl group wherein the hydrogen atoms may be wholly or partly replaced by fluorine atoms, or
- a phenyl group optionally substituted by one to three substituents selected from C1-3-alkyl groups, halogen atoms, cyano or nitro groups, wherein the substituents may be identical or different.
Dependencies are inferred from the claim text.