Scaffolds for cell transplantation
AssigneesPresident and Fellows of Harvard College, The Regents of the University of Michigan
InventorsDavid J. Mooney, Omar Abdel-Rahman Ali, Eduardo Alexandre Barros e Silva, Hyun Joon Kong, Elliott Earl Hill, Jr., Tanyarut Boontheekul
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Abstract
A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.
Claims23
A method of inducing an endogenous immune response to a cancer target, comprising
- administering to a mammal a device comprising a scaffold composition, said scaffold composition comprising open, interconnected macropores, a recruitment composition incorporated in or on said scaffold composition, and a target antigen composition
- wherein an endogenous antigen presenting cell is recruited into said device where said cell encounters said target antigen and where said cell resides until a deployment signal induces egress of said cell via said open, interconnected macropores to a lymph node tissue outside of said device, wherein the level of immune activation of said cell at egress is greater than that prior to entering said device, and wherein said recruitment composition comprises a growth factor, cytokine, or chemokine that attracts bodily cells to said device, said target antigen comprises a cancer antigen, and said deployment signal comprises a factor that induces migration of said cell, thereby stimulating an endogenous immune response to said cancer target.
Dependencies are inferred from the claim text.