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US 8,067,195 B2Granted
Process for producing 7-methoxy-3-desacetylcefalotin
AssigneeACS DOBFAR S.p.A.
InventorsAuro Roberto Tagliani, Gabriele Guastalegname, Giovanni Fogliato, Riccardo Monguzzi
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Abstract
The invention relates to a method for preparing 7-methoxy-3-desacetylcefalotin by a hydrolysis process which takes place in water and is catalyzed by an enzyme obtained from Bacillus pumulis possessing acetyl hydrolasic activity.
Claims5
A process for preparing the compound of formula I:
- in which the compound of formula II:
- is subjected to hydrolysis of the acetyl group, wherein said hydrolysis is conducted in water in the presence of a catalyst consisting of at least one enzyme obtained from Bacillus pumilus possessing acetyl hydrolasic activity, thus forming an aqueous reaction medium, at a temperature between 0° C. and +20° C. and at a pH between 6 and 8.
A process comprising:
- (1) subjecting the compound of formula II:
- to hydrolysis of the acetyl group to produce the compound of formula I:
- wherein said hydrolysis is conducted in water in the presence of a catalyst consisting of at least one enzyme obtained from Bacillus pumilus possessing acetyl hydrolasic activity, thus forming an aqueous reaction medium, at a temperature between 0° C. and +20° C. and at pH between 6 and 8;
- and
- (2) isolating the compound of formula I by extracting the aqueous reaction medium with a solvent.
2 more elements
Dependencies are inferred from the claim text.