Modified vaccinia virus strains for use in diagnostic and therapeutic methods
AssigneeGenelux Corporation
InventorsAladar A. Szalay, Alexa Frentzen, Yong A. Yu, Nanhai Chen, Qian Zhang
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Abstract
Modified viruses and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including cancer, and as anti-tumor and/or antiangiogenic agents. The viruses also can be used in diagnostic methods.
Claims29
A method of treatment of cancer, comprising administering a LIVP virus to a subject for the treatment of a tumor or metastasis, wherein the LIVP virus contains heterologous nucleic acid encoding an anti-vascular endothelial growth factor (VEGF) antibody or an antibody fragment thereof, wherein:
- the LIVP virus comprises an inactivated the hemagglutinin (HA) gene locus, thymidine kinase (TK) gene locus or F14.5L gene;
- and
- the anti-VEGF antibody or fragment thereof is inserted into a non-essential locus in the virus operatively linked to a promoter for expression.
Dependencies are inferred from the claim text.