Attenuated poliovirus
AssigneeThe Research Foundation of State University of New York
InventorsEckard Wimmer, Jeronimo Cello, Aniko Paul, Hidemi Toyoda, Jiang Yin
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Abstract
A novel and stable attenuated poliovirus, which replicates in neuroblastoma cells, is produced by engineering an indigenous replication element (cre), into the 5′ non-translated genomic region and inactivating the native cre element located in the coding region of 2C (mono-crePV). The stably attenuated poliovirus replicates in a neuroblastoma model (Neuro-2aCD155 tumors) expressing CD155, the poliovirus receptor, and is effective for oncolytic treatment and cure of solid tumors, such as neuroblastoma.
Claims10
A method of treating a tumor in a subject, comprising:
- administering to the tumor a therapeutically effective amount of a composition comprising a recombinant poliovirus containing a single active cre regulatory element, said cre element located in the spacer region of the 5′-NTR between the cloverleaf and internal ribosome entry site (IRES);
- wherein the recombinant poliovirus infects and lyses tumor cells.
Dependencies are inferred from the claim text.