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US 8,063,187 B2Granted
Methods and compositions for inhibiting CD32B expressing cells
AssigneeXencor, Inc.
InventorsSeung Yup Chu, John R. Desjarlais, Sher Bahadur Karki, Gregory Alan Lazar, Gregory L. Moore, Igor Vostiar
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Abstract
The present invention relates to immunoglobulins that bind FcγRIIb+ cells and coengage the antigen on the cell's surface and an FcγRIIb on the cell's surface, methods for their generation, and methods for using the immunoglobulins.
Claims2
A variant anti-CD19 antibody comprising:
- a light chain comprising an amino acid sequence of SEQ ID NO:
- 7;
- and
- a heavy chain comprising an amino acid sequence of SEQ ID NO:
- 9.
2 more elements
Dependencies are inferred from the claim text.