Biomagnetic detection and treatment of Alzheimer's Disease
AssigneeScientific Nanomedicine, Inc.
InventorEdward R. Flynn
Life of this patent
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Abstract
SQUID imaging of a subject's head after the subject having been administered superparamagnetic nanoparticles comprising: an iron-containing core, a coating covering the core and a probe molecule conjugated to the coating wherein the probe molecule locates the superparamagnetic nanoparticle to a target in the brain that is characteristic of the neurodegenerative disease; magnetizing the superparamagnetic nanoparticles using external magnetic coils; and measuring the decaying remanence magnetic fields of the superparamagnetic nanoparticles attached to the target and not from unattached superparamagnetic nanoparticles to obtain magnetic field measurements.
Claims18
A method for in-vivo detection of neurodegenerative disease comprising:
- SQUID imaging of a subject's head after the subject having been administered superparamagnetic nanoparticles comprising an iron-containing core, a coating covering the core, and a probe molecule conjugated to the coating wherein the probe molecule locates the superparamagnetic nanoparticle to a target in the brain that is characteristic of the neurodegenerative disease;
- magnetizing the superparamagnetic nanoparticles using external magnetic coils with a field strength and application time that causes the superparamagnetic nanoparticles attached to the target to produce magnetic remanence fields lasting more than a microsecond but less than tens of seconds;
- measuring the decaying remanence magnetic fields of the superparamagnetic nanoparticles attached to the target and not from unattached superparamagnetic nanoparticles to obtain magnetic field measurements;
- and
- detecting neurodegenerative disease from the magnetic field measurements and the magnetic properties of the superparamagnetic nanoparticles.
A method for in-vivo detection of Alzheimer's Disease comprising:
- determining the location and amount of amyloid plaques in the brain associated with Alzheimer's Disease comprising:
- SQUID imaging of a subject's head after the subject having been administered a plurality of superparamagnetic nanoparticles comprising an iron-containing core, a coating, and a probe that is conjugated to each superparamagnetic nanoparticle for locating each superparamagnetic nanoparticle to a target comprising amyloid plaque;
- wherein SQUID imaging comprises magnetizing the plurality of superparamagnetic nanoparticles using external magnetic coils with a field strength and application time that causes each of the superparamagnetic nanoparticles attached to the target to produce magnetic remanence fields lasting more than a microsecond but less than tens of seconds;
- measuring the emitted decaying fields from only those superparamagnetic nanoparticles that have attached to the target and not from those superparamagnetic nanoparticles that have not attached to the target to obtain magnetic field measurements;
- determining the location and quantity of the target in the brain from the magnetic field measurements;
- and
- detecting Alzheimer's Disease from the location and quantity of the target in the brain.
Dependencies are inferred from the claim text.