Antibodies specific for N-terminal truncated and pyroglutamate modified amyloid-beta peptides

An isolated antibody comprising:

• (i) a light chain comprising a variable part, the variable part of the light chain of said antibody comprising a polypeptide (a) encoded by a nucleotide sequence selected from the group consisting of SEQ ID NO:
• 49, SEQ ID NO:
• 53, SEQ ID NO:
• 57 and SEQ ID NO:
• 61 or (b) having an amino acid sequence selected from the group consisting of SEQ ID NO:
• 50, SEQ ID NO:
• 54, SEQ ID NO:
• 58, and SEQ ID NO:
• 62;
• or
• (ii) a heavy chain comprising a variable part;
• the variable part of the heavy chain of said antibody comprising a polypeptide (a) encoded by a nucleotide sequence selected from the group consisting of SEQ ID NO:
• 51, SEQ ID NO:
• 55, SEQ ID NO:
• 59 and SEQ ID NO:
• 63 or (b) having an amino acid sequence selected from the group consisting of SEQ ID NO:
• 52, SEQ ID NO:
• 56, SEQ ID NO:
• 60 and SEQ ID NO:
• 64,
• wherein,
• the isolated antibody binds to an Aβ peptide or variant thereof.