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US 8,058,255 B2Granted
Methods and compositions concerning siRNA's as mediators of RNA interference
AssigneeApplied Biosystems, LLC
InventorsLance P. Ford, Joseph Krebs
Life of this patent
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Abstract
The present invention concerns an isolated siRNA of from about 5 to about 20 nucleotides that mediates RNA interference. Also disclosed are methods of reducing expression of a target gene in a cell comprising obtaining at least one siRNA of 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20 basepairs in length; and delivering the siRNA into the cell. The siRNAs can be chemically synthesized RNA or an analog of a naturally occurring RNA.
Claims19
A composition comprising isolated dsRNA, wherein the isolated dsRNA comprises a nucleotide sequence selected from the group consisting of SEQ ID NO:
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Dependencies are inferred from the claim text.