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US 8,058,069 B2Granted
Lipid formulations for nucleic acid delivery
AssigneeProtiva Biotherapeutics, Inc.
InventorsEdward Yaworski, Kieu Lam, Lloyd Jeffs, Lorne Palmer, Ian MacLachlan
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Abstract
The present invention provides novel, stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles. More particularly, the present invention provides stable nucleic acid-lipid particles (SNALP) comprising a nucleic acid (such as one or more interfering RNA), methods of making the SNALP, and methods of delivering and/or administering the SNALP.
Claims22
A nucleic acid-lipid particle comprising:
- (a) a nucleic acid;
- (b) a cationic lipid comprising from 50 mol % to 65 mol % of the total lipid present in the particle;
- (c) a non-cationic lipid comprising a mixture of a phospholipid and cholesterol or a derivative thereof, wherein the phospholipid comprises from 4 mol % to 10 mol % of the total lipid present in the particle and the cholesterol or derivative thereof comprises from 30 mol % to 40 mol % of the total lipid present in the particle;
- and
- (d) a conjugated lipid that inhibits aggregation of particles comprising from 0.5 mol % to 2 mol % of the total lipid present in the particle.
2 more elements
Dependencies are inferred from the claim text.