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US 8,057,992 B2Granted
Methods for identifying peptides that bind to intact oocytes
AssigneeAuburn University
InventorsTatiana I. Samoylova, Henry J. Baker, Brenda Griffin, Kristina Pendergrass, Ludmila P. Globa, M. Daniel Givens, Kay P. Riddell, Nancy Cox
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Abstract
Disclosed are methods, compositions, and zona pellucida binding peptides and polypeptides for use in immunocontraception of canines and other animals. The disclosed compositions may include pharmaceutical compositions. Methods for identifying peptides that bind to intact oocytes also are provided, in particular methods for identifying peptides that bind to zona pellucida of intact oocytes.
Claims9
A method for identifying a peptide that binds to intact oocytes, the method comprising
- (a) isolating intact oocytes;
- (b) contacting no more than 1000 of the intact oocytes with a phage library;
- (c) selecting phage that bind to the intact oocytes, thereby identifying peptides that bind to the intact oocytes.
Dependencies are inferred from the claim text.