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US 8,053,220 B2Granted
Choroid plexus device
AssigneeThe Invention Science Fund I, LLC
InventorsEd Harlow, Roderick A. Hyde, Edward K. Y. Jung, Robert Langer, Eric C. Leuthardt, Lowell L. Wood, Jr.
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Abstract
Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.
Claims18
A device comprising:
- a semi-permeable component comprising a confluent tissue coating of choroid plexus epithelial cells cultured on a porous scaffold;
- at least one structural component that is at least partially composed of porous bone that is in contact with and supports the semi-permeable component;
- wherein the semi-permeable component either substantially surrounds the at least one structural component or the semi-permeable component is substantially surrounded by the at least one structural component;
- wherein the device forms an internal cavity that is substantially surrounded by the semi-permeable component and the porous bone;
- wherein the semi-permeable component has at least one characteristic of the choroid plexus epithelium that is different from the characteristics of the peripheral epithelium.
2 more elements
Dependencies are inferred from the claim text.