Long-acting polypeptides and methods of producing same
AssigneeModigene Inc
InventorsFuad Fares, Udi Eyal Fima
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Abstract
A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a carboxy terminus of a cytokine are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.
Claims25
A polypeptide consisting of a cytokine, one chorionic gonadotrophin carboxy terminal peptide (CTP) attached to the amino terminus of said cytokine, and two chorionic gonadotrophin carboxy terminal peptides attached to the carboxy terminus of said cytokine.
A polypeptide consisting of a cytokine, one chorionic gonadotrophin carboxy terminal peptide (CTP) attached to the amino terminus of said cytokine, two chorionic gonadotrophin carboxy terminal peptides attached to the carboxy terminus of said cytokine, and a signal peptide attached to the amino terminus of said one CTP.
A method of extending the biological half life of a cytokine, consisting of the step of attaching one chorionic gonadotrophin carboxy terminal peptide (CTP) to the amino terminus of said cytokine and two chorionic gonadotrophin carboxy terminal peptides to the carboxy terminus of said cytokine, thereby extending the biological half life of a cytokine.
A method of extending the biological half life of a cytokine, consisting of the step of attaching one chorionic gonadotrophin carboxy terminal peptide (CTP) to the amino terminus of said cytokine, two chorionic gonadotrophin carboxy terminal peptides to the carboxy terminus of said cytokine and a signal peptide to the amino terminus of said one CTP, thereby extending the biological half life of a cytokine.
Dependencies are inferred from the claim text.