Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
AssigneeArtecel Sciences, Inc.
InventorsYuan-Di C. Halvorsen, William O. Wilkison, Jeffrey M. Gimble
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Abstract
Methods and compositions for directing adipose-derived stromal cells cultivated in vitro to differentiate into cells of the chondrocyte lineage are disclosed. The invention further provides a variety of chondroinductive agents which can be used singly or in combination with other nutrient components to induce chondrogenesis in adipose-derived stromal cells either in cultivating monolayers or in a biocompatible lattice or matrix in a three-dimensional configuration. Use of the differentiated chondrocytes for the therapeutic treatment of a number of human conditions and diseases including repair of cartilage in vivo is disclosed.
Claims8
A method of treating a cartilage defect in a mammal, the method comprising:
- a) producing a synthetic cartilage patch, wherein said synthetic cartilage patch comprises an isolated adipose tissue derived stromal cell that has been differentiated in vitro to express at least one characteristic of a chondrocyte;
- and
- b) surgically implanting said synthetic cartilage patch to a cartilage defect area in said mammal.
Dependencies are inferred from the claim text.