System and method for identifying networks of ternary relationships in complex data systems
AssigneeThe Regents of the University of California
InventorKer-Chau Li
Life of this patent
Estimating the term…
Abstract
A system and method for identifying high order associations between variables in complex systems that is particularly useful where there is no correlation or weak correlation between variables due to the influence of a third variable, a ternary relationship. The ternary relationship describes how the variation in the pattern of association between a pair of variables, including its sign and strength, is mediated by a third variable. In one embodiment applied to gene expression data, the activity of pairs of correlated genes due to the activity of one or more third genes is shown.
Claims18
A method for determining liquid associations between gene expression, comprising:
- providing a database of gene expression profiles;
- executing a computer program on a computer device to carry out steps comprising:
- preparing a liquid association database from said gene expression profiles;
- identifying associations between genes from said liquid association database;
- and
- displaying the liquid association database and the identified associations between genes on a display.
A method for determining liquid associations between gene expression, the method comprising:
- providing a database of gene expression profiles;
- executing a computer program on a computer device to carry out steps comprising:
- refining the gene expression profiles of said database by conducting a normal score transformation of said gene expression profiles to produce a refined database;
- computing a liquid association of paired transformed gene expression profiles with a third transformed gene expression profile to provide a set of associated gene expression profiles;
- identifying associations between genes from the set of associated gene expression profiles;
- and
- verifying the identified associations between genes identified from the set of associated gene expression profiles within a cell.
Dependencies are inferred from the claim text.