Adaptive linear filter for real time noise reduction in surface plasmon resonance systems
AssigneeGeneral Electric Company
InventorDavid So Keung Chan
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Abstract
A method for linear filtering of noise in a SPR sensorgram generated from a surface plasmon resonance apparatus is provided. The method includes providing a linear filter of variable length to filter an output signal in the sensorgram. The method further includes determining an optimal length of the linear filter based on a slope of the signal in the sensorgram and multiple timing of occurrences of events during measurement of refractive index in the apparatus to reduce noise in the sensorgram.
Claims20
A method for linear filtering of noise in a sensorgram generated from a surface plasmon resonance apparatus, the method comprising:
- providing a linear filter of variable length to filter an output signal in the sensorgram;
- and
- determining an optimal length of the linear filter based on a slope of the signal in the sensorgram and a plurality of timing of occurrences of events during measurement of refractive index in the apparatus to reduce noise in the sensorgram.
A method for linear filtering of noise in a sensorgram generated from a surface plasmon resonance apparatus, the method comprising:
- providing a linear filter of variable length to filter an output signal in the sensorgram;
- determining a first filter length based on a plurality of timings of occurrences of events during measurement of surface plasmon resonance in the apparatus;
- determining a second filter length based on a slope of the signal between the plurality of events;
- comparing the first filter length and the second filter length;
- and
- selecting a shorter length between the first filter length and the second filter length.
A linear filtering system for filtering noise in a surface plasmon resonance sensorgram, the system comprising:
- a SPR measurement apparatus for generating a sensorgram;
- a processor for receiving the sensorgram, which processor is configured to:
- provide a linear filter of variable length to filter an output signal in the sensorgram;
- determine a first filter length based on a plurality of timings of occurrences of events during measurement of refractive index in the apparatus;
- determine a second filter length based on a slope of a signal between the plurality of events;
- compare the first filter length and the second filter length;
- and
- select a shorter length between the first filter length and the second filter length.
Dependencies are inferred from the claim text.