Arrangement and method for influencing and/or detecting magnetic particles in a region of action

An arrangement for influencing and/or detecting magnetic particles in a region of action, wherein the arrangement comprises:

• a generator configured to generate a magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action;
• a driver configured to change a position in space of the two sub-zones in the region of action by a magnetic drive field so that the magnetization of the magnetic particles changes locally, the arrangement comprising a drive signal chain;
• a receiver configured to acquire detection signals, which detection signals depend on the magnetization in the region of action, wherein the magnetization is influenced by the change in the position in space of the first sub-zone and second sub-zone, the arrangement comprising a detection signal chain;
• and
• a compensation controller configured to provide a compensation signal to the drive signal chain and/or to the detection signal chain by a coupler,
• wherein the compensation controller is provided with a feedback signal from the drive signal chain and/or from the detection signal chain, and
• wherein the feedback signal is generated by an additional receiver.

An arrangement for influencing and/or detecting magnetic particles in a region of action, wherein the arrangement comprises:

• a generator configured to generate a magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action;
• a driver configured to change a position in space of the two sub-zones in the region of action by a magnetic drive field so that the magnetization of the magnetic particles changes locally, the arrangement comprising a drive signal chain;
• a receiver configured to acquire detection signals, which detection signals depend on the magnetization in the region of action, wherein the magnetization is influenced by the change in the position in space of the first sub-zone and second sub-zone, the arrangement comprising a detection signal chain;
• and
• a compensation controller configured to provide a compensation signal to the drive signal chain and/or to the detection signal chain by a coupler,
• wherein the compensation controller is provided with a feedback signal from the drive signal chain and/or from the detection signal chain, and
• wherein the feedback signal is generated using measuring points at the coupler.

A method for influencing and/or detecting magnetic particles in a region of action, wherein the method comprises the acts of:

• generating a magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action;
• changing the position in space of the two sub-zones in the region of action by a magnetic drive field formed by drive signals so that the magnetization of the magnetic particles changes locally;
• acquiring detection signals, wherein the detection signals depend on the magnetization in the region of action, wherein the magnetization is influenced by the change in the position in space of the first sub-zone and second sub-zone,
• compensating the drive signals and/or the detection signals a compensation signal coupled to the drive signals and/or coupled to the detection signals;
• wherein the compensation signal is generated by:
• measuring calibration variations in the drive signal and/or in the detection signals or applying calibration variations of the compensation signal to the drive signals and/or to the detection signals, and
• computing the compensation signal.

A method for calibrating an arrangement for influencing and/or detecting magnetic particles in a region of action, wherein the method comprises the acts of:

• generating a magnetic selection field having a pattern in space of its magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action;
• changing a position in space of the two sub-zones in the region of action by a magnetic drive field formed by drive signals;
• acquiring detection signals, wherein the detection signals depend on the magnetic drive field and/or on a magnetization of the magnetic particles in the region of action, and wherein the magnetization is influenced by the change in the position in space of the first sub-zone and second sub-zone;
• generating a compensation signal coupled to the drive signals and/or coupled to the detection signals, wherein the compensation signal is generated by:
• measuring calibration variations in the drive signal and/or in the detection signals or applying calibration variations of the compensation signal to the drive signals and/or to the detection signals, and
• computing the compensation signal.