2-(aryloxy) acetamide factor VIIa inhibitors useful as anticoagulants

A compound of Formula (II):

• or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein:
• W is substituted with 0-2 R6 and selected from:
• X1 and X2 are, independently at each occurrence, H or NH2;
• Z is selected from:
• R1 is H, F, Cl, Br, C1-3 alkyl substituted with 0-1 OH, C1-3 haloalkyl, C2-3 alkenyl,
• C2-3 alkynyl, —O—C1-3 alkyl, or C3-6 cycloalkyl;
• R2 and R3 are, independently at each occurrence, H, F, Cl, Br, I, ORa, SRa, OCF3, OCHF2, OCH2F, CN, NO2, —NRbRc, —C(O)Ra, —CO2Ra, —NRdC(O)Ra, —C(O)NRcRd, —NRcC(O)ORa, —NRcC(O)NRcRd, —SO2NRcRd, —NRcSO2NRcRd, —NRcSO2Ri, —NRcSO2CF3, —SO2CF3, —S(O)pRi, —(CF2)rCF3, C1-4 alkyl substituted with 0-2 Re, C2-4 alkenyl substituted with 0-2 Re, or C2-4 alkynyl substituted with 0-2 Re;
• R4 is, independently at each occurrence, H, F, Cl, Br, I, ORa, SRa, OCF3, CN, NO2, —NRbRc, —C(O)Ra, —CO2Ra, —NRdC(O)Ra, —C(O)NRcRd, —NRcC(O)ORa, —NRcC(O)NRcRd, —SO2NRcRd, —NRcSO2NRcRd, —NRcSO2Ri, —NRcSO2CF3, —SO2CF3, —S(O)pRi, —(CF2)rCF3, C1-4 alkyl substituted with 0-2 Re, C2-4 alkenyl substituted with 0-2 Re, or C2-4 alkynyl substituted with 0-2 Re;
• R6 is, independently at each occurrence, F, Cl, CH3, OH or CF3;
• R7 is H, C1-4 alkyl, —CH2CO2Ra, —CH2CH2CO2Ra, —CH2CH2OH, —CH2CH2CH2OH, tetrazolyl, —CH2CONHSO2Re, or —CH2CH2CONHSO2Re;
• R8 is H, C1-4 alkyl, CO2Ra, —CH2CO2Ra, —CH2OH, —CH2CH2OH, tetrazolyl, —CONHSO2Re, or —CH2CONHSO2Re;
• R9 is H or Me;
• R10a and R10b are, independently at each occurrence, H, F, Cl, Br, I, SRa, SCF3, CN, NO2, —B(OH)2, —C(O)Ra, —(CH2)r—CO2Ra, —(CH2)r—NRcCO2Ra, —NRdC(O)Ra, —(CH2)r—C(O)NRcRd, —NRcC(O)NRcRd, —SO2NRcRd, —OSO2NRcRd, —NRcSO2NRcRd, —NRcSO2Ri, —NRcSO2CF3, —SO2CF3, —S(O)pRi, —(CF2)rCF3, C1-6 alkyl substituted with 0-2 Re, C2-6 alkenyl substituted with 0-2 Re, or C2-6 alkynyl substituted with 0-2 Re;
• Ra is, independently at each occurrence, H, C1-6 alkyl substituted with 0-4 Rh, —(CH2), C3-7 carbocycle substituted with 0-4 Rf, or —(CH2),-5- to 10-membered heterocycle comprising:
• carbon atoms and 1-4 heteroatoms selected from N, NRg, O, and S(O)p, wherein said heteroaryl is substituted with 0-4 Rf;
• Rb is, independently at each occurrence, H, C1-6 alkyl, —(CH2)n-phenyl, (C1-6 alkyl)C(O)—, (C3-6 cycloalkyl)-C0-4 alkyl-C(O)—, (C6-10 aryl)-(C0-4 alkyl)-C(O)—, (5- to 10-membered heteroaryl)-C0-4 alkyl-C(O)—, (C1-6 alkyl)-NHC(O)—, (C1-6 alkyl)2-NHC(O)—, (C6-10 aryl)-C0-4 alkyl-NHC(O)—, (5- to 10-membered heteroaryl)-C0-4 alkyl-NHC(O)—, (C1-6 alkyl)-SO2—, (C6-10 aryl)-C0-4 alkyl-SO2—, or (5- to 10-membered heteroaryl)-C0-4 alkyl-SO2—, wherein said phenyl, aryl and heteroaryl are substituted with 0-2 Rf;
• Rc is, independently at each occurrence, H, C1-6 alkyl substituted with 0-3 Rh, —(CH2)n—C3-7 cycloalkyl substituted with 0-3 Rh, or —(CH2)n-phenyl substituted with 0-3 Rh;
• Rd is, independently at each occurrence, H, C1-6 alkyl, —(CH2)r—C3-10 carbocycle substituted with 0-3 Rf, or a —(CH2)r-5- to 12-membered heterocycle comprising:
• carbon atoms and 1-4 heteroatoms selected from N, NRg, O, and S(O)P, wherein said heterocycle is substituted with 0-3 Rf;
• Re is, independently at each occurrence, ═O, ORa, F, Cl, Br, I, CN, NO2, —SRa, —OCF3, —NRbRc,
• —C(O)Ra, —CO2Ra, —NRdC(O)Ra, —C(O)NRcRd, —OC(O)Ra, —NRdC(O)ORa, —NRdC(O)NRcRd, —OC(O)NRcRd, —SO2NRcRd, —NC(O)ORa, —NRcSO2NRcRd, —NRcSO2Ri, —NRcSO2CF3,
• —SO2CF3, —S(O)pRi, —(CF2)rCF3, C3-10 carbocycle substituted with 0-3 Rf, or a 5- to 12-membered heterocycle comprising:
• carbon atoms and 1-4 heteroatoms selected from N, NRg, O, and S(O)p, wherein said heterocycle is substituted with 0-3 Rf;
• Rf is, independently at each occurrence, ═O, ORE, F, Cl, Br, I, CN, NO2, —SRg, —OCF3, —NRcRc,
• —C(O)Rg, —CO2Rg, —NRcC(O)Rg, —C(O)NRcRc, —OC(O)Rg, —NRcC(O)ORg, —NRcC(O)NRcRc, —OC(O)NRcRc, —SO2NRcRc, —NRcSO2NRcRc, —NRcSO2Ri, —NRCSO2CF3, —SO2CF3,
• —S(O)pRi, —(CF2)rCF3, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocycle substituted with 0-3 Rh, or a 5- to 12-membered heterocycle comprising:
• carbon atoms and 1-4 heteroatoms selected from N, NRg, O, and S(O)p, and substituted with 0-3 Rh;
• Rg is, independently at each occurrence, H, C1-6 alkyl, or —(CH2)n-phenyl;
• Rh is, independently at each occurrence, ═O, —(CH2)rORg, F, Cl, Br, I, CN, NO2, —OCF3, —NRgRg, —C(O)Rg, —CO2Rg, —NRgC(O)Rg, —C(O)NRgRg, —SO2NRgRg, —NRgSO2NRgRg,
• —NRgSO2—C1-4 alkyl, —NRgSO2CF3, —NRgSO2-phenyl, —SO2CF3, —S(O)p—C1-4 alkyl, —S(O)p-phenyl, —(CF2)rCF3, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, (C1-6 alkyl)C(O)—, (C3-6 cycloalkyl)-C0-4 alkyl-C(O)—, (C6-10 aryl)-(C0-4 alkyl)-C(O)—, (5-10 membered heteroaryl)-C0-4 alkyl-C(O)—, (C1-6 alkyl)-NHC(O)—, (C1-6 alkyl)2-NHC(O)—, (C6-10 aryl)-C0-4 alkyl-NHC(O)—, (5-10 membered heteroaryl)-C0-4 alkyl-NHC(O)—,
• (C1-6 alkyl)-SO2—, (C6-10 aryl)-C0-4 alkyl-SO2—, (5-10 membered heteroaryl)-C0-4 alkyl-SO2—,
• —(CH2)r—C3-10 carbocycle, or a —(CH2)r-5- to 12-membered heterocycle comprising:
• carbon atoms and 1-4 heteroatoms selected from N, NRg, O, and S(O)p;
• Ri is, independently at each occurrence, H, C1-6 alkyl substituted with 0-3 Rh, C3-6 cycloalkyl substituted with 0-3 Rh, —(CH2)n-phenyl substituted with 0-3 Rh, —(CH2)r-5-to 10-membered heterocycle comprising:
• carbon atoms and 1-4 heteroatoms selected from N, NRg, O, and S(O)p, wherein said heterocycle is substituted with 0-3 Rh;
• n, at each occurrence, is selected from 0, 1, 2, 3, and 4;
• p, at each occurrence, is selected from 0, 1, and 2;
• and
• r, at each occurrence, is selected from 0, 1, 2, 3, and 4.