Bioabsorbable surgical composition
AssigneeTyco Healthcare Group LP
InventorsAhmad R. Hadba, Walter Skalla, Nadya Belcheva
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Abstract
Compounds are provided which can form bioabsorbable compositions useful as adhesives or sealants for medical/surgical applications. In embodiments, suitable compositions may possess various functional groups, including groups derived from multifunctional compounds, aliphatic or aromatic groups, groups derived from aliphatic diacids, groups derived from a dihydroxy compound, and combinations thereof. Methods for forming these compositions, as well as uses thereof, are also provided.
Claims2
A branched isocyanate functional compound prepared by reacting at least two different aliphatic polyester macromers of the formula
- HO—(R-A)n-R—OH
- wherein A is an acid selected from the group consisting of sebacic acid, azelaic acid, suberic acid, pimelic acid, adipic acid, glutaric acid, succinic acid, malonic acid, oxalic acid and combinations thereof;
- R can be the same or different at each occurrence and comprises a dihydroxy compound selected from the group consisting of polyethylene oxides, polypropylene oxides, block or random copolymers of polyethylene oxides and polypropylene oxides, and polyethylene glycols having a molecular weight less than 1,000;
- and n is 1 to 10, with at least one diisocyanate in a single reaction to provide a mixture of diisocyanate-endcapped macromers;
- and reacting the mixture of diisocyanate-endcapped macromers with a multifunctional compound in a single reaction to provide a mixture of branched isocyanate functional compounds.
Dependencies are inferred from the claim text.