Fluoroboron compound, aminomethylating agent for aromatic ring made of the same, and production method of compound containing aminomethyl aromatic ring using aminomethylating agent
AssigneeEisai R&D Management Co., Ltd.
InventorKeigo Tanaka
Life of this patent
Estimating the term…
Abstract
A production method of a compound containing a primary, secondary, or tertiary aminomethyl aromatic ring of the present invention includes: using a fluoroboron compound or a dimer thereof, or solvates thereof, which are represented by a formula (I): Ra(Rb)N—CH2—BF3M (I) as an aminomethylating agent for an aromatic ring; and reacting the aminomethylating agent with an aromatic ring-containing compound, which can react with the aminomethylating agent, under the presence of a metal catalyst such as a palladium compound so as to perform the direct aminomethylation of the aromatic ring.
Claims4
A compound represented by a formula (III):
- wherein M represents an alkali metal cation, [N(R1)(R2)(R3)(R4)]+, or [P(R1)(R2) (R3)(R4)]+,
- R1, R2, R3 and R4 each independently represents a C1-6 alkyl group or a C7-15 aralkyl group, and
- X represents a hydrogen atom, a C1-6 alkyl group, or a nitro group.
Dependencies are inferred from the claim text.