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US 8,044,213 B2Granted
Thiazolyl-benzimidazoles
AssigneeHoffmann-La Roche Inc.
InventorsJianping Cai, Shaoqing Chen, Yi Chen, Xin-Jie Chu, Robert Alan Goodnow, Jr., Kang Le, Kin-Chun Luk, Steven Gregory Mischke, Peter Michael Wovkulich
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Abstract
The invention is directed to compounds of formula (1) and pharmaceutically acceptable salts thereof, methods for the preparation thereof, and methods of use thereof.
Claims15
A compound of formula (I)
- wherein
- A is selected from the group consisting of phenyl, 2-chlorophenyl, 3-chlorophenyl, 4-chlorophenyl, 2-trifluoromethylphenyl, 3-trifluoromethylphenyl, and 4-trifluoromethylphenyl;
- R1 is selected from the group consisting of H, and OCH3;
- R2 is Z-Q-R3,
- wherein Z is selected from the group consisting of nothing, O, and C(O)
- Q is selected from the group consisting of (CH2)m and CH2CH(OH)CH2 and
- m is an integer from 0 to 4;
- R3 is selected from the group consisting of
- and —NR4, R5;
- R4 and R5 are independently selected from the group consisting of H, CH3, (CH2)2OH, (CH2)2,
- X is selected from the group consisting of CH and N;
- Y is selected from the group consisting of O, CHR6, and NR7,
- wherein
- must contain at least one nitrogen atom;
- R6 is selected from the group consisting of H, NH2 and NHC(O)R8;
- R7 is selected from the group consisting of H, CH3, and (CH2)2OH;
- R8 is selected from the group consisting of OtBu, OC(CH3)2NH2, OC(CH3)2NHC(O)OtBu,
- and
- pharmaceutically acceptable salts thereof.
16 more elements
Dependencies are inferred from the claim text.