Substance having antioxidant, geroprotective and anti-ischemic activity and method for the preparation thereof
AssigneeMarvel Lifesciences Limited
InventorsLeonid Dmitrievich Smirnov, Michail Arkadievich Ostrovsky, Aleksey Michailovich Sipyagin, Aleksandr Evgenievich Doncov
Life of this patent
Estimating the term…
Abstract
The invention relates to the field of medicine, namely to new biologically active compounds, particularly to 2,4,6-trimethyl-3-hydroxypyridine derivatives and salts thereof (compound 1) having antioxidant, geroprotective and anti-ischemic action. The salts of compound (1) are prepared by reacting equimolecular quantities of 2,4,6-trimethyl-3-hydroxypyridine and dicarboxylic in solution of a lower alcohol at a temperature of 60-100° C. with following treatment of the reaction mass with an organic solvent and maintaining for 2-5 h at 10-15 ° C.
Claims1
A method for preparing a pharmaceutically acceptable salt of 2,4,6-trimethyl-3-hydroxypyridine with a lower dicarboxylic acid, of formula (I)
- wherein
- X is selected from the group consisting of a single bond, —CH2—, —CH2CH2—, and —CH2CH(OH)—said salt having antioxidant, geroprotective and anti-ischemic activity, said method comprising:
- reacting equimolar amounts of 2, 4, 6-trimethyl-3-hydroxypyridine and a dicarboxylic acid in a solution of a lower alcohol at boiling temperature,
- treating the resulting reaction mixture with an organic solvent;
- and,
- optionally, maintaining the reaction mixture for 2-5 h at 10-15° C.
Dependencies are inferred from the claim text.