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US 8,044,181 B2Granted
Antibodies to the PcrV antigen of Pseudomonas aeruginosa
AssigneeKaloBios Pharmaceuticals, Inc.
InventorsChristopher R. Bebbington, Kenneth Luehrsen, Geoffrey T. Yarranton, Mark Baer
Life of this patent
Estimating the term…
Abstract
The current invention provides high-affinity antibodies to the Pseudomonas aeruginosa PcrV protein that have reduced immunogenicity when administered to treat Pseudomonas aeruginosa infections.
Claims15
An isolated anti-PcrV antibody that binds to PcrV, comprising:
- a VH region that comprises a CDR3 having a sequence NRGDIYYDFTYAMDI (SEQ ID NO:99), a CDR2 sequence VISYDGSEKWYADSVKG (SEQ ID NO:57), and a CDR1 sequence NYPMH (SEQ ID NO:54);
- and a VL region that comprises a CDR3 having a sequence QHFWGTPYT (SEQ ID NO:110), a CDR2 sequence DASTLQS (SEQ ID NO:73) and a CDR1 sequence RASEGVDRWLA (SEQ ID NO:69).
An isolated anti-PcrV antibody that is an antagonist of the Type III secretion system, comprising:
- a VH region having the amino acid sequence set forth in SEQ ID NO:26 and a VL region having the amino acid sequence set forth in SEQ ID NO:24.
Dependencies are inferred from the claim text.