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US 8,044,179 B2Granted
Methods and compositions for modulating tumor cell activity
AssigneeNational Research Council of Canada
InventorsMaureen D. O'Connor-McCourt, Christiane Cantin, Anne E. G. Lenferink
Life of this patent
Estimating the term…
Abstract
Antibodies which target clusterin, a protein involved in the epithelial-to-mesenchymal transition of carcinoma cells, are identified and characterized. The antibodies may be used to modulate tumour cell activity through binding to clusterin.
Claims29
An isolated antibody which specifically binds to an epitope of clusterin located between amino acids 421 and 443 selected from the group consisting of:
- a) an antibody comprising three complementarity-determining regions of a light chain variable region set forth in SEQ ID NO.:8 and three complementarity-determining regions of a heavy chain variable region set forth in SEQ ID NO.:20;
- b) an antibody comprising three complementarity-determining regions of a light chain variable region set forth in SEQ ID NO.:9 and three complementarity-determining regions of a heavy chain variable region set forth in SEQ ID NO.:20,
- c) an antibody comprising three complementarity-determining regions of a light chain variable region set forth in SEQ ID NO.:10 and three complementarity-determining regions of a heavy chain variable region set forth in SEQ ID NO.:21;
- d) an antibody comprising three complementarity-determining regions of a light chain variable region set forth in SEQ ID NO.11 and three complementarity-determining regions of a heavy chain variable region set forth in SEQ ID NO. :22;
- and
- e) an antibody comprising three complementarity-determining regions of a light chain variable region set forth in SEQ ID NO.:12 and three complementarity-determining regions of a heavy chain variable region set forth in SEQ ID NO.:23.
3 more elements
An isolated antibody which specifically binds to an epitope of clusterin located between amino acids 421 and 443 and which comprises:
- a) a light chain variable region as set forth in SEQ ID NO.:
- 8 and a heavy chain variable region as set forth in SEQ ID NO.:20;
- b) a light chain variable region as set forth in SEQ ID NO.:9 and a heavy chain variable region as set forth in SEQ ID NO.:20;
- c) a light chain variable region as set forth in SEQ ID NO.:
- 10 and a heavy chain variable region as set forth in SEQ ID NO.:21;
- d) a light chain variable region as set forth in SEQ ID NO.:
- 11 and a heavy chain variable region as set forth in SEQ ID NO.:
- 22, or
- e) a light chain variable region as set forth in SEQ ID NO.:
- 12 and a heavy chain variable region as set forth in SEQ ID NO.:23.
7 more elements
Dependencies are inferred from the claim text.