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US 8,044,175 B2Granted
Peptides that specifically bind HGF receptor (CMET) and uses thereof
AssigneesDyax Corp., Bracco Suisse SA
InventorsDaniel T. Dransfield, Aaron Sato, Robert Charles Ladner, Palaniappa Nanjappan
Life of this patent
Estimating the term…
Abstract
A polypeptide or multimeric polypeptide construct having the ability to bind to cMet or a complex comprising cMet and HGF, and methods for use are disclosed.
Claims4
A polypeptide or multimeric polypeptide comprising the amino acid sequence:
- Gly-X1-Cys-X2-Cys-X3-Gly-Pro-Pro-X4-Phe-X5-Cys-X6-Cys-X7-X8-X9-X10-Pro (SEQ ID NO:534), wherein
- X1 is Ser;
- X2 is His, Tyr or Asn;
- X3 is Ser or Gly;
- X4 is any amino acid other than Cys;
- X5 is Glu;
- X6 is Trp;
- X7 is Tyr;
- X8 is Gly, Asp, Ala, Glu or Ser;
- X9 is Thr or Ser;
- and
- X10 is Glu or Asp.
9 more elements
Dependencies are inferred from the claim text.