Actinically-crosslinkable silicone-containing block copolymers
AssigneeNovartis AG
InventorsFrank Chang, Guigui Wang
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Abstract
The invention provide a new class of silicone-containing prepolymers containing poly(oxyalkylene) blocks, polysiloxane blocks, and actinically-crosslinkable groups which are acryl groups, thiol groups, ene-containing groups or combinations thereof. A prepolymer of the invention is prepared in a one-pot procedure according to the Michael addition of thiol to electron deficient alkenes, such as α,β-unsaturated carbonyl compounds, without need for additional reaction step(s) to introduce actinically crosslinkable groups. The present invention is also related to silicone hydrogel contact lenses made from this class of silicone-containing prepolymers and to methods for making the silicone hydrogel contact lenses.
Claims15
An actinically crosslinkable prepolymer, comprises:
- poly(oxyalkylene) blocks;
- polysiloxane blocks;
- and actinically-crosslinkable groups,
- wherein the block copolymer is obtained by copolymerizing a mixture comprising
- (1) at least one linear poly(oxyalkylene) with two first reactive groups,
- (2) at least one linear polysiloxane with two second reactive groups,
- (3) a branched poly(oxyalkylene) with multiple first reactive groups, a branched polysiloxane with multiple second reactive groups, or combination thereof, and
- (4) optionally a hetero difunctional compound having one ene-containing group and one first or second reactive group,
- wherein the first and second reactive groups, different from each other, are either thiol groups or acryl groups and undergo Michael addition reaction to form carbon-sulfur bonds.
Dependencies are inferred from the claim text.