Nitrosation-inducible inhibitors biological macromolecules
AssigneeNew York University
InventorsEvgeny Nudler, Audrei Nedospasov
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Abstract
Biomacromolecules such as proteins are inactivated by hydrophobic ANSA derivatives of the formula: wherein R1 and R2 are hydrophobic or affinity groups and R3 is selected from the group consisting of aminoacyl groups and peptidyl groups upon nitrosation. ANSA derivatives can be designed to selectively kill tumor cells and various pathogens, including bacteria, viruses, and fungi.
Claims9
A method for inactivating at least one protein in a host suffering from cancer or an infection by a pathogen comprising administering to said host to inactivate cancer cells or pathogens an effective amount of an ANSA compound of the formula:
- wherein at least one of R1 and R2 are selected from the group consisting of hydrogen;
- C1-C30 alkyl, arylalkyl or alkylaryl;
- C1-30 alkyl halide, alkenyl, alkenyl halide;
- with the proviso that at least one of R1 and R2 is a hydrophobic group, and R3 is selected from the group consisting of amino acyl groups and peptidyl groups.
A method for inactivating at least one protein in a host suffering from cancer or an infection comprising administering to said host to inactivate cancer cells or pathogens an effective amount of an ANSA derivative of the formula:
- wherein R1, R2 and R4 are selected from the group consisting of C1-C30 alkyl, alkyl halide, alkenyl, alkenyl halide, aryl, arylalkyl, and aryl and arylalkyl halides and at least one of R1, R2 or R4 is a hydrophobic group;
- and R3 is an amino acyl or a peptide group, or R1 and R2 with nitrogen form a cyclic group.
Dependencies are inferred from the claim text.