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US 8,044,087 B2Granted
Hepatitis C virus inhibitors
AssigneeBristol-Myers Squibb Company
InventorsAlan Xiangdong Wang, Ramkumar Rajamani, Paul Michael Scola
Life of this patent
Estimating the term…
Abstract
Hepatitis C virus inhibitors having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
Claims17
A compound of formula (I)
- or a pharmaceutically acceptable salt thereof, wherein
- R1 is selected from hydroxy and —NHSO2R5;
- R2 is selected from hydrogen, alkenyl, alkyl, and cycloalkyl, wherein the alkenyl, the alkyl, and the cycloalkyl are each optionally substituted with one, two, three, or four halo groups;
- R3 is a phenyl group substituted with an additional phenyl or a heterocyclyl wherein the additional phenyl and the heterocyclyl can be further optionally substituted with one, two, three, four, or five substituents independently selected from alkoxy, alkyl, cyano, halo, haloalkoxy, haloalkyl, and hydroxy;
- R4 is selected from hydrogen, alkoxycarbonyl, alkyl, alkylcarbonyl, alkylsulfonyl, cycloalkyloxycarbonyl, haloalkoxycarbonyl, haloalkyl, haloalkylcarbonyl, haloalkylsulfonyl, (NRaRb)carbonyl, and (NRaRb)sulfonyl, wherein the cycloalkyl part of the cycloalkyloxycarbonyl is optionally substituted with one, two, or three haloalkyl groups;
- R5 is selected from alkyl, aryl, arylalkyl, cycloalkyl, (cycloalkyl)alkyl, heterocyclyl, and —NRaRb;
- wherein the alkyl and cycloalkyl are each optionally substituted with one group selected from alkyl, alkoxy, halo, haloalkyl, cyano, cyanoalkyl, and haloalkoxy;
- Ra and Rb are independently selected from hydrogen, alkoxy, alkyl, aryl, arylalkyl, cycloalkyl, (cycloalkyl)alkyl, haloalkyl, heterocyclyl, and heterocyclylalkyl;
- X is selected from O, S, SO, and SO2;
- and
- Q is a C5-9 saturated or unsaturated chain optionally substituted with one or two groups independently selected from alkyl, halo, and haloalkyl.
8 more elements
A compound selected from
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.