N-phenylacetamide inhibitors of the enzyme SOAT-1 and pharmaceutical/cosmetic compositions comprised thereof

An N-phenylacetamide compound having the following general formula (I):

• in which:
• Y is C(0) or CH2,
• R1 is a (C1-C6)alkyl radical,
• R2 is a hydrogen, chlorine, fluorine or bromine atom, or a (C1-C6)alkyl radical,
• R3 is a hydrogen atom, a (C1-C6)alkyl radical, or a —WNR6R7 radical wherein W is C(O), C(S) or CH2, R6 is a hydrogen atom or a (C1-C6)alkyl radical and R7 is a hydrogen atom, a cycloalkyl radical or a phenyl radical,
• R4 and R′4 are identical and are each a (C1-C6)alkyl radical or else R4 and R′4 are bonded to one another and together form, with the carbon atom from which they depend, a cycloalkyl group,
• R5 is a group selected from among:
• (i) an unsubstituted phenyl radical or a phenyl radical substituted by one to three identical or different substituents selected from among the atoms fluorine, chlorine, iodine or bromine, and the radicals (C1-C6)alkyl, hydroxymethyl, mono-, di- or trifluoromethyl, hydroxyl, phenyl, 2-pyridyl, 3-pyridyl or 4-pyridyl, (C1-C6)alkoxy, phenoxy, benzyloxy, mono-, di- or trifluoromethoxy,
• (ii) a (C1-C12)alkyl radical, optionally substituted by one or more hydroxyl groups, or fluorine, chlorine, iodine or bromine atoms,
• (iii) a cycloalkyl radical or a -(CH2)m-cycloalkyl radical in which m is equal to 1, 2 or 3,
• (iv) an aralkyl radical —(CH2)n-Ar with n equal to 1, 2 or 3 and Ar is an unsubstituted phenyl radical, unsubstituted naphthyl, or a phenyl radical substituted by one to three identical or different substituents selected from among the atoms fluorine, chlorine, iodine and bromine, and the radicals (C1-C6)alkyl, hydroxymethyl, mono-, di- or trifluoromethyl, hydroxyl, phenyl, 2-pyridyl, 3-pyridyl or 4-pyridyl, (C1-C6)alkoxy, phenoxy, benzyloxy, mono-, di- or trifluoromethoxy, and the pharmaceutically acceptable salts, conformers and rotamers thereof.