Aminoderivative of biotin and their conjugates with macrocyclic chelating agents

A complex of a compound of formula (I)

• where:
• Q is a —(CH2)n— group, in which n is an integer from 4 to 12, in which case R′ does not exist, or Q is selected from the group consisting of —(CH2)a—CH(R′)—(CH2)b— where a and b are independently 0 or h, wherein h is an integer from 4 to 12, R′ is as defined here below, or Q is cyclohexyl, phenyl, in which case R′ is a substituent on the cyclohexyl or phenyl ring;
• R is hydrogen or -Λ, where -Λ is a formula (II) macrocycle
• where the various Ys, which may be the same or different, are selected from the group consisting of hydrogen, a C2 alkyl group, straight or branched C3-C4 alkyl, —(CH2)m—COOH, where m is an integer from 1 to 3;
• X is hydrogen or the —CH2—U group, where U is selected from methyl, ethyl, p-aminophenyl, or X is the —(CHW)o—Z group, where o is an integer from 1 to 5, W is hydrogen, methyl or ethyl, Z is a heterocyclic group with 5 or 6 members containing one or more heteroatoms selected from O, N—R1, R1 being a hydrogen, C1-C2 alkyl group, or a straight or branched C3-C4 alkyl group, and S;
• or Z is selected from —NH2, —NH—C(═NH)—NH2, or —S—R2 where R2 is a C1 or C2 alkyl group or a straight or branched C1-C4 alkyl group;
• p is the integer 2 or 3;
• R′ is selected from the group consisting of hydrogen, a C1-C2 alkyl group, a straight or branched C3-C4 alkyl, —(CH2)q-T, where T is selected from the group consisting of S—CH3, —OH, or —COOH, and q is the integer 1 or 2;
• R″ has the same meaning as R, with the following conditions:
• if R is -Λ, R″ is hydrogen;
• if R is hydrogen R″ is -Λ, or R and R″ are (CH2)r-Λ(for R), where r is an integer from 4 to 12, and -Λ (for R″) respectively, Q being a —(CH2)n— group where n is an integer from 4 to 12
• with a radioisotope.