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US 8,044,075 B2Granted
IL-8 receptor antagonists
AssigneeGlaxoSmithKline LLC
InventorsGregory L. Adams, James A. Brackley, III, Jakob Busch-Petersen, Jianghe Deng, Wei Fu, Huijie Li, Jack J. Taggart, Feng Wang, Yonghui Wang, Katherine Louisa Widdowson, Hongyi Yu
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Abstract
This invention relates to novel compounds, compositions and combinations thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
Claims16
A compound of Formula (I):
- wherein:
- Y is halogen;
- n is 0, 1 or 2;
- X is halogen;
- Ra is selected from the group consisting of hydrogen, C1-4alkyl, C3-6cycloalkyl, C3-6cycloalkylC1-4alkyl, and phenyl, wherein all moieties, except hydrogen, are optionally substituted, one to three times, by halogen, CF3, OH or C1-4alkyl;
- and
- Rb is selected from the group consisting of phenyl, C1-4alkyl, phenylC1-4alkyl, C3-6cycloalkyl, phenylC3-6cycloalkyl and heteroaryl, wherein all moieties are optionally substituted, one to four times, by halogen, CF3 or C1-4alkyl;
- or a pharmaceutically acceptable salt thereof.
5 more elements
Dependencies are inferred from the claim text.