Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus replication

A compound having the formula

• a N-oxide, addition salt, or a stereochemically isomeric form thereof;
• wherein
• G is a direct bond or C1-10alkanediyl optionally substituted with one or more substituents independently selected from the group of substituents consisting of hydroxy, C1-6alkyloxy, Ar1C1-6alkyloxy, C1-6alkylthio, Ar1C1-6alkylthio, HO(—CH2—CH2—O)n—, C1-6alkyloxy(—CH2—CH2—O)n— or Ar1C1-6alkyloxy(—CH2—CH2—O)n—;
• each n independently is 1, 2, 3 or 4;
• R1 is pyridyl;
• wherein said pyridyl may optionally be substituted with 1 or where possible more, substituents independently selected from the group of substituents consisting of halo, hydroxy, amino, cyano, carboxyl, C1-6alkyl, C1-6alkyloxy, C1-6alkylthio, C1-6alkyloxyC1-6alkyl, Ar1, Ar1C1-6alkyl, Ar1C1-6alkyloxy, hydroxyC1-6alkyl, mono-or di(C1-6alkyl)amino, mono-or di(C1-6alkyl)aminoC1-6alkyl, polyhaloC1-6alkyl, C1-6alkylcarbonylamino, C1-6alkyl-SO2—NR5c—, Ar1—SO2—NR5c—, C1-6alkyloxycarbonyl, —C(═O)—NR5cR5d, HO(—CH2—CH2—O)n—, halo(—CH2—CH2—O)n—, C1-6alkyloxy(—CH2—CH2—O)n—, Ar1C1-6alkyloxy(—CH2—CH2—O)n— and mono-or di(C1-6alkyl)amino(—CH2—CH2—O)n—;
• each t independently is 0, 1 or 2;
• Q is hydrogen, amino or mono- or di(C1-4alkyl)amino;
• R2a and R3a are each independently selected from hydrogen, halo, optionally mono- or polysubstituted C1-6alkyl, optionally mono- or polysubstituted C2-6alkenyl, nitro, hydroxy, Ar2, N(R4aR4b), N(R4aR4b)sulfonyl, N(R4aR4b)carbonyl, C1-6alkyloxy, Ar2oxy, Ar2C1-6alkyloxy, carboxyl, C1-6alkyloxycarbonyl, or —C(═Z)Ar2;
• wherein ═Z is ═O, ═CH—C(═O)—NR5aR5b, ═CH2, ═CH—C1-6alkyl, ═N—OH or ═N—O—C1-6alkyl;
• and wherein the optional substituents on C1-6alkyl and C2-6alkenyl can be the same or can be different relative to one another, and are each independently selected from the group of substituents consisting of hydroxy, cyano, halo, nitro, N(R4aR4b), N(R4aR4b)sulfonyl, Ar2, C1-6alkyloxy, C1-6alkyl-S(═O)t, Ar2oxy, Ar2—S(═O)t, Ar2C1-6alkyloxy, Ar2C1-6alkyl-S(═O)t, carboxyl, C1-6alkyloxycarbonyl and —C(═Z)Ar2;
• provided that when R2a is halo, optionally mono- or polysubstituted C1-6alkyl, optionally mono- or polysubstituted C2-6alkenyl, nitro, hydroxy, Ar2, N(R4aR4b), N(R4aR4b)sulfonyl, N(R4aR4b)carbonyl, C1-6alkyloxy, Ar2oxy, Ar2C1-6alkyloxy, carboxyl, C1-6alkyloxycarbonyl, or —C(═Z)Ar2;
• then R3a is hydrogen;
• and
• provided that when R3a is halo, optionally mono- or polysubstituted C1-6alkyl, optionally mono- or polysubstituted C2-6alkenyl, nitro, hydroxy, Ar2, N(R4aR4b), N(R4aR4b)sulfonyl, N(R4aR4b)carbonyl, C1-6alkyloxy, Ar2oxy, Ar2C1-6alkyloxy, carboxyl, C1-6alkyloxycarbonyl, or —C(═Z)Ar2;
• then R2a is hydrogen;
• R2b and R3b are each independently selected from hydrogen, C1-6alkyl or halogen;
• provided that when R2a is halo, optionally mono- or polysubstituted C1-6alkyl, optionally mono- or polysubstituted C2-6alkenyl, nitro, hydroxy, Ar2, N(R4aR4b)sulfonyl, N(R4aR4b)sulfonyl, N(R4aR4b)carbonyl, C1-6alkyloxy, Ar2oxy, Ar2C1-6alkyloxy, carboxyl, C1-6alkyloxycarbonyl, or —C(═Z)Ar2 then R2b is hydrogen, C1-6alkyl or halogen and R3b is hydrogen;
• and
• provided that when R3a is halo, optionally mono- or polysubstituted C1-6alkyl, optionally mono- or polysubstituted C2-6alkenyl, nitro, hydroxy, Ar2, N(R4aR4b), N(R4aR4b)sulfonyl, N(R4aR4b)carbonyl, C1-6alkyloxy, Ar2oxy, Ar2C1-6alkyloxy, carboxyl, C1-6alkyloxycarbonyl, or —C(═Z)Ar2 then R3b is hydrogen, C1-6alkyl or halogen and R2b is hydrogen;
• R4a and R4b can be the same or can be different relative to one another, and are each independently selected from the group of substituents consisting of hydrogen, C1-6alkyl, Ar2C1-6alkyl, (Ar2)(hydroxy)C1-6alkyl, hydroxyC1-6alkyl, mono- and di-(C1-6alkyloxy)C1-6alkyl, (hydroxyC1-6alkyl)oxyC1-6alkyl, Ar1C1-6alkyloxy-C1-6alkyl, dihydroxyC1-6alkyl, (C1-6alkyloxy)(hydroxy)C1-6alkyl, (Ar1C1-6alkyloxy)(hydroxy)C1-6alkyl, Ar1oxy-C1-6alkyl, (Ar1oxy)(hydroxy)-C1-6alkyl, aminoC1-6alkyl, mono- and di(C1-6alkyl)amino-C1-6alkyl, carboxyl-C1-6alkyl, C1-6alkyloxycarbonylC1-6alkyl, aminocarbonylC1-6alkyl, mono- and di(C1-6alkyl)aminocarbonylC1-6alkyl, C1-6alkylcarbonylC1-6alkyl, (C1-4alkyloxy)2-P(═O)—C1-6alkyl, (C1-4alkyloxy)2P(═O)—O—C1-6alkyl, aminosulfonyl-C1-6alkyl, mono- and di(C1-6alkyl)aminosulfonyl-C1-6alkyl, C1-6alkylcarbonyl, Ar2carbonyl, Ar2C1-6alkylcarbonyl, C1-6alkylsulfonyl, aminosulfonyl, mono- and di(C1-6alkyl)aminosulfonyl, Ar2sulfonyl, Ar2C1-6alkylsulfonyl, Ar2;
• R5a and R5b can be the same or can be different relative to one another, and are each independently hydrogen or C1-6alkyl;
• or
• R5c and R5d taken together may form a bivalent radical of formula —(CH2)s— wherein s is 4 or 5;
• R5c and R5d can be the same or can be different relative to one another, and are each independently hydrogen or C1-6alkyl;
• or
• R5c and R5d taken together may form a bivalent radical of formula —(CH2)s— wherein s is 4 or 5;
• R6a is hydrogen, C1-6alkyl, Ar1, Ar1C1-6alkyl, C1-6alkylcarbonyl, Ar1carbonyl, Ar1C1-6alkylcarbonyl, C1-6alkylsulfonyl, Ar1sulfonyl, Ar1C1-6alkylsulfonyl, C1-6alkyloxyC1-6alkyl, aminoC1-6alkyl, mono- or di(C1-6alkyl)aminoC1-6alkyl, hydroxyC1-6alkyl, (carboxyl)-C1-6alkyl, (C1-6alkyloxycarbonyl)-C1-6alkyl, aminocarbonylC1-6alkyl, mono- and di(C1-6alkyl)aminocarbonylC1-6alkyl, aminosulfonyl-C1-6alkyl, mono- and di(C1-6alkyl)aminosulfonyl-C1-6alkyl;
• R6b is hydrogen, C1-6alkyl, Ar1 or Ar1C1-6alkyl;
• R6c is C1-6alkyl, Ar1 or Ar1C1-6alkyl;
• Ar1 is phenyl or phenyl substituted with 1 or more, substituents selected from halo, hydroxy, C1-6alkyl, hydroxyC1-6alkyl, polyhaloC1-6alkyl, and C1-6alkyloxy;
• Ar2 is phenyl, phenyl annelated with C5-7cycloalkyl, or phenyl substituted with 1 or more, substituents selected from halo, cyano, C1-6alkyl, Ar1—C1-6alkyl, cyanoC1-6alkyl, C2-6alkenyl, cyanoC2-6alkenyl, R6b—O—C3-6alkenyl, C2-6alkynyl, cyanoC2-6alkynyl, R6b—O—C3-6alkynyl, Ar1, R6b—O—, R6b—S—, R6c—SO—, R6c—SO2—, R6b—O—C1-6alkyl-SO2—, —N(R6aR6b), polyhalo-C1-6alkyl, polyhaloC1-6alkyloxy, polyhaloC1-6alkylthio, R6c—C(═O)—, R6b—O—C(═O)—, N(R6aR6b)—C(═O)—, R6b—O—C1-10alkyl, R6b—S—C1-6alkyl, R6c—S(═O)2—C1-6alkyl, N(R6aR6b)—C1-6alkyl, R6c—C(═O)—C1-6alkyl, R6b—O—C(═O)—C1-6alkyl, N(R6aR6b)—C(═O)—C1-6alkyl, R6c—C(═O)—NR6b—, R6c—C(═O)—O—, R6c—C(═O)—NR6b—C1-6alkyl, R6c—C(═O)—O—C1-6alkyl, N(R6aR6b)—S(═O)2—, H2N—C(═NH)—.