Pyrrole derivatives, preparation thereof and therapeutic use thereof

A compound of the formula (I):

• in which:
• A represents:
• a (C1-C6)alkylene group, which is unsubstituted or substituted one or more times with a (C1-C3)alkyl group;
• a group
• wherein m=0, 1 or 2 and p=0 or 1;
• R1 represents hydrogen or a (C1-C4)alkyl;
• R2 represents:
• a (C3-C10)alkyl group, which is unsubstituted or substituted with a trifluoromethyl group;
• hydroxyl, (C1-C4)alkoxy, a fluorine atom or a CONH2 group;
• a non-aromatic C3-C12 carbocyclic radical, which is unsubstituted or substituted one or more times with a (C1-C4)alkyl, hydroxyl, cyano or (C1-C4)alkoxy group, a group COR12 or a fluorine atom;
• an indanyl;
• a 1,2,3,4-tetrahydro-1- or -2-naphthyl;
• a monooxygen or monosulfur heterocyclic radical of 5 to 7 atoms, which is unsubstituted or substituted one or more times with a (C1-C4)alkyl group;
• a mononitrogen heterocyclic radical of 5 to 7 atoms, which is unsubstituted or substituted one or more times with a (C1-C4)alkyl group, the nitrogen atom moreover being substituted with a (C1-C4)alkyl, phenyl, benzyl, (C1-C4)alkoxycarbonyl or (C1-C4)alkanoyl group, the phenyl or benzyl groups being unsubstituted or substituted one or more times with a halogen atom or a (C1-C4)alkyl, trifluoromethyl, hydroxyl or (C1-C4)alkoxy group;
• a benzothiophenyl or an indolyl, the said radicals being unsubstituted or substituted one or more times with a (C1-C4)alkyl group;
• a (C1-C3)alkylene group bearing a non-aromatic C3-C10 carbocyclic radical, which is unsubstituted or substituted one or more times with a (C1-C4)alkyl, hydroxyl, (C1-C4)alkoxy or cyano group or a group COR12;
• a (C1-C3)alkylene group bearing a monooxygen, monosulfur or mononitrogen heteroaromatic or non-heteroaromatic heterocyclic radical of 5 to 7 atoms, which is unsubstituted or substituted one or more times with a (C1-C4)alkyl group;
• a (C1-C3)alkylene group bearing an indolyl or benzothiophenyl radical, the said radical being unsubstituted or substituted one or more times with a (C1-C4)alkyl group and the alkylene being unsubstituted or substituted with a hydroxyl, methyl or methoxy group or with a group COR12;
• a (C1-C3)alkylene group bearing a (C1-C4)alkylthio group;
• a phenylalkylene group in which the alkylene is (C1-C3), which is unsubstituted or substituted on the alkylene with one or more methyl, hydroxyl, hydroxymethyl, methoxy or methoxymethyl groups, or a group COR12, and which is unsubstituted on the phenyl or substituted on the phenyl with one or more identical or different substituents chosen from a halogen atom and a (C1-C4)alkyl, trifluoromethyl, (C1-C4)alkoxy or trifluoromethoxy group;
• a benzhydryl or benzhydrylmethyl group;
• a group NR10R11;
• or R1 and R2, together with the nitrogen atom to which they are attached, constitute:
• either a morpholinyl group
• or a piperazin-1-yl or 1,4-diazepan-1-yl radical, which is unsubstituted or substituted with a phenyl, benzyl, benzodioxolyl, benzodioxolylmethyl or tetrahydrofurylcarbonyl group or with a group COR12 or CH2COR12, the benzyl group itself being unsubstituted or substituted with one or more halogen atoms or with one or more methoxy or methoxymethyl groups;
• or a piperid-1-yl, pyrrolidin-1-yl or azetidin-1-yl radical, which is unsubstituted or substituted one or two times with a substituent independently chosen from:
• a fluorine atom or a group (C1-C4)alkyl, hydroxyl, cyano, COR12, NR13R14, NHCOR15, CH2COR12, SO2Alk;
• or SO2NR13R14;
• a phenyl, benzyl or pyridyl group, the said phenyl, benzyl or pyridyl groups being unsubstituted or substituted one or more times with a substituent each independently chosen from a halogen atom, and a methyl, trifluoromethyl, hydroxyl, (C1-C4)alkoxy or cyano group;
• a piperid-1-yl, pyrrolidin-1-yl or azetidin-1-yl group, the said piperid-1-yl, pyrrolidin-1-yl or azetidin-1-yl groups being unsubstituted or substituted one or more times with a fluorine atom or a (C1-C4)alkyl, (C1-C4)alkoxy, hydroxyl, trifluoromethyl or OCF3 group;
• R3, R4, R5, R6, R7 and R8 represent, independently of each other, a hydrogen or halogen atom, a group CN, S(O)nALK or OS(O)nALK, a group (C1-C7)alkyl, which is unsubstituted or substituted one or more times with a substituent each independently chosen from a fluorine atom, and group OALK, S(O)nALK, OS(O)nALK and NHSO2Alk, or a group (C1-C6)alkoxy, which is unsubstituted or substituted with one or more substituents each independently chosen from a fluorine atom and a group OALK, S(O)nALK, OS(O)nALK and NHSO2Alk;
• R9 represents a group —OH, —CN, —CO2H, NR13R14, —CONR13R14, —NR1COR13, —CONHNH2, —CONHOH, —CONHSO2Alk, —S(O)nAlk, —SO2CF3, —SO2NR13R14, —NR1SO2Alk, —NR1SO2CF3, —NR1SO2NR13R14, or a radical chosen from:
• R10 represents a hydrogen atom or a methyl group;
• R11 represents a (C3-C6)alkyl, phenyl or (C3-C10)cycloalkyl group, the phenyl and cycloalkyl groups being unsubstituted or substituted with one or more substituents independently chosen from a halogen atom and a (C1-C4)alkyl or trifluoromethyl group;
• or R10 and R11, together with the nitrogen atom to which they are attached, constitute a saturated or unsaturated, bridged or non-bridged heterocyclic radical of 4 to 11 atoms, possibly comprising a spirane carbon and possibly containing a second heteroatom chosen from O and N, the said radical being unsubstituted or substituted one or more times with a substituent each independently chosen from a hydroxyl, (C1-C4)alkyl or (C1-C4)alkoxycarbonyl or COR12 group, or a phenyl group that is unsubstituted or substituted with one or more substituents independently chosen from a halogen atom and a (C1-C4)alkyl group;
• R12 represents a (C1-C4)alkyl, phenyl, benzyl, (C1-C4)alkoxy or trifluoromethyl group or a group NR13R14;
• R13 and R14 each independently represent a hydrogen atom or a (C1-C6)alkyl group optionally substituted with one or more groups OH, F or OALK, or R13 or R14, together with the nitrogen atom to which they are attached, constitute a 4- to 7-membered heterocyclic radical possibly comprising a second heteroatom chosen from a nitrogen, oxygen or sulfur atom;
• R15 represents a (C1-C4)alkyl or trifluoromethyl group;
• n represents 0, 1 or 2;
• ALK represents a (C1-C4)alkyl group, which is unsubstituted or substituted with one or more fluorine atoms;
• and
• Alk represents a (C1-C4)alkyl group;
• or a salt thereof.