Compounds as calcium channel blockers

A compound of formula (I),

• or a pharmaceutically acceptable salt thereof, wherein
• is a single or double bond;
• n, at each occurrence, is independently 1 or 2;
• X is CH2;
• r, at each occurrence, is independently 0, 1, or 2;
• Ar1 and Ar2 are independently aryl or heteroaryl;
• wherein each Ar1 and Ar2 is independently unsubstituted or further substituted with 1, 2, 3, 4, or 5 substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, halogen, —CN, —NO2, —ORa, —S(Rc), —S(O)(Rc), —S(O)2Rc, —S(O)2N(Rb)2, —C(O)Rb, —C(O)O(Rb), —C(O)N(Rb)2, —N(Rb)2, —N(Rb)C(O)Rb, —N(Rb)C(O)O(Rb), —N(Rb)S(O)2Rc, haloalkyl, —(CRdRe)m—ORa, —(CRdRe)m—S(Rc), —(CRdRe)m—S(O)(Rc), —(CRdRe)m—S(O)2Rc, —(CRdRe)m—S(O)2N(Rb)2, —(CRdRe)m—C(O)Rb, —(CRdRe)m—C(O)O(Rb), —(CRdRe)m—C(O)N(Rb)2, —(CRdRe)m—N(Rb)2, —(CRdRe)m—N(Rb)C(O)Rb, —(CRdRe)m—N(Rb)C(O)O(Rb), —(CRdRe)m—N(Rb)S(O)2Rc, and —CH═CH-heteroaryl-(CRdRe)m—O(alkyl);
• Ra, at each occurrence, is independently hydrogen, alkyl, haloalkyl, or —(CRdRe)m—O(alkyl);
• Rb, at each occurrence, is independently hydrogen, alkyl, haloalkyl, or G1;
• Rc, at each occurrence, is independently alkyl or haloalkyl;
• Rd and Re, at each occurrence, are each independently hydrogen, halogen, alkyl, or haloalkyl;
• m, at each occurrence, is independently 1, 2, 3, 4, 5, or 6;
• L1 is —(CH2)pC(O)— or —(CH2)p—;
• wherein
• p, at each occurrence, is independently 1, 2, 3, or 4;
• L2 is —N(R5)—, —N(R5)—(CH2)q—, —NH—CH(R5)—, —NH—CH(R5)—(CH2)q—, —N(R5)—CH2CH(OH)CH2—, —N(R5)—CH(R6)—, (i), (iv), (v), (vi), (vii), (viii), (ix), (x), (xi) or (xii);
• q, at each occurrence, is independently 1, 2, or 3;
• w is 1, 2, 3, or 4;
• x is 2, 3, 4, or 5;
• y at each occurrence, is independently 1, 2, or 3;
• z at each occurrence, is independently 0, 1, 2, or 3;
• R5 at each occurrence, is hydrogen, alkyl, or G1;
• Rii at each occurrence, is independently oxo or alkyl;
• Riii is hydrogen, alkyl, or aryl;
• Riv is hydrogen, aryl, ORa or part of double bond between L2 and Y;
• Rvi is hydrogen or alkyl;
• X1 is CH2, NH, O, or a bond;
• A1 and A3 are independently C or N;
• A2, A4, and A5 are each independently CH, CR5, N, O, or S;
• one of A6, A7, A8, A9, and A10 is C and the others are each independently CH or N;
• Y is a bond, CR2R3, CH2CR2R3, CR2, CR2R3O, C(O), C(O)OCR2R3, N—O—CR2R3, O, or S(O)r;
• R2 is hydrogen or G1;
• R3 is hydrogen, alkyl, cycloalkyl, or hydroxyl;
• or
• R2 and R3 taken together with the carbon atom to which they are attached form a cycloalkyl;
• G1, at each occurrence, is independently aryl, heteroaryl, heterocycle, cycloalkyl, or cycloalkenyl;
• wherein each G1 is independently unsubstituted or further substituted with 1, 2, 3, 4, 5, or 6 substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, halogen, oxo, —CN, —NO2, —ORa, —S(Rc), —S(O)(Rc), —S(O)2Rc, haloalkyl, —(CRdRe)m—ORa, —(CRdRe)m—S(Rc), —(CRdRe)m—S(O)(Rc), and —(CRdRe)m—S(O)2Rc;
• R1 is hydrogen, alkyl, or G1;
• and
• R4 is hydrogen;
• or
• R3 and R5 taken together are —(CH2)p— or —O—(CH2)p—;
• or
• R4 and R5 taken together are a bond, —(CH2)s—, or —O—(CH2)s—;
• wherein
• s, at each occurrence, is independently 1 or 2;
• or
• R4 and R6 taken together are —CH2—;
• or
• L1-L2Y taken together are S(O)r;
• with the provisos that
• Ar2 is other than a pyrazole substituted with 1 or 2 groups independently selected from aryl and heteroaryl;
• or
• when Ar1 is aryl or heteroaryl, R1 is aryl or heteroaryl, X is CH2, n is 1, L1 is —(CH2)p—, Y is CR2R3, Ar2 is aryl, and R4 is H, then L2 is other than —N(R5)—, —N(R5)—(CH2)q—, or —NH—CH(R5)—;
• or
• when Ar1 and R1 are both unsubstituted phenyl, X is CH2, n is 2, L1 is —CH2C(O)—, L2 is —N(CH3)—(CH2)3—, Y is CR2R3, Ar2 is unsubstituted phenyl, and R4 is hydrogen, then R2 is other than unsubstituted phenyl;
• or
• when Ar1 is phenyl, R1 is hydrogen or methyl, X is CH2, n is 1, L1-L2Y taken together are S(O)r, r is 2, then Ar2 is other than 4-methylphenyl;
• or
• when the bond connecting L2 to Y is a double bond, Y is CR2;
• or
• when X is other than CH2, n is 2.