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US 8,044,063 B2Granted
Quinazoline derivatives useful as anti-tumor medicament
AssigneeShanghai Allist Pharmaceuticals, Inc.
InventorsJianhui Guo, Meng Wang, Yong Jiang, Xiaofang Zhang
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Abstract
The present invention relates to quinazoline derivatives of the formula (I) useful as anti-tumor medicaments, or a pharmaceutically acceptable salt thereof, the definition of the substituents R1, R1′, R2, R2′ are as defined in the description. It also relates to a pharmaceutical composition containing same, and a method for the preparation of quinazoline derivatives of formula (I) or a pharmaceutically acceptable salt thereof.
Claims4
A compound of formula I, or a pharmaceutically acceptable salt, thereof,
- wherein
- R1 is acylamino of the formula:
- wherein R3 is selected from hydrogen, N,N-dimethylaminomethyl, N,N-diethylaminomethyl, N,N-dipropylaminomethyl and N-morpholinomethyl;
- R1′ is selected from hydrogen, C1-C4 alkyl, C1-C4 alkyl substituted by halogens, C1-C4 alkoxy, or C1-C4 alkoxy substituted by halogens, and
- R2 is selected from benzyloxy, mono-, di- and tri-halobenzyloxy;
- and
- R2′ is halogen.
4 more elements
Dependencies are inferred from the claim text.