Adenine compound
AssigneesDainippon Sumitomo Pharma Co., Ltd., AstraZeneca Aktiebolag
InventorsYoshiaki Isobe, Tomoaki Nakamura
Life of this patent
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Abstract
A novel adenine compound represented by the formula (1): [wherein R1 is substituted or unsubstituted alkyl, etc., X is oxygen, etc., A1 is 4- to 8-membered substituted or unsubstituted saturated nitrogen-containing heterocycle containing 1 to 2 hetero atom(s) selected from 1 to 2 nitrogen(s), 0 to 1 oxygen and 0 to 1 sulfur, etc., A2 is substituted or unsubstituted 6- to 10-membered aryl, etc., L1 and L2 are independently a straight chain or branched chain alkylene, etc.], or a pharmaceutically acceptable salt thereof, which is useful as a medicament.
Claims10
An adenine compound of the formula (1):
- [wherein R1 is a halogen atom, a substituted or unsubstituted C1-12 alkyl group, a substituted or unsubstituted C2-10 alkenyl group, a substituted or unsubstituted C2-10 alkynyl group, a substituted or unsubstituted C3-8 cycloalkyl group, a substituted or unsubstituted 6- to 10-membered aryl group, or a substituted or unsubstituted 5- to 10-membered heteroaryl group,
- X is an oxygen atom, a sulfur atom, NR2 (R2 is a hydrogen atom or a C1-6 alkyl group), SO, SO2 or a single bond (when R1 is a halogen atom, then X is a single bond),
- A1 is a 4- to 8-membered substituted or unsubstituted, saturated nitrogen-containing heterocycle or an unsaturated non-aromatic nitrogen-containing heterocycle, said heterocycle containing 1 to 2 heteroatom(s) selected from 1 to 2 nitrogen atom(s), 0 to 1 oxygen atom and 0 to 1 sulfur atom,
- A2 is a substituted or unsubstituted 6- to 10-membered aryl group or a substituted or unsubstituted 5- to 10-membered heteroaryl group,
- L1 and L2 are independently a C1-12 alkylene group, a C2-12 alkenylene group, or a single bond, and any 1 to 3 methylene group(s) in said alkylene group or alkenylene group may be replaced by an oxygen atom, a sulfur atom, NR3 (R3 is a hydrogen atom or a C1-6 alkyl group), SO, SO2, or a carbonyl group],
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.