Back to results
US 8,044,055 B2Granted
2-phenyl-6-aminocarbonyl-pyrimidine derivatives and their use as P2Y12 receptor
AssigneeActelion Pharmaceuticals Ltd.
InventorsEva Caroff, Kurt Hilpert, Emmanuel Meyer
Life of this patent
Estimating the term…
Abstract
The invention relates to 2-phenyl-6-aminocarbonyl-pyrimidine derivatives and their use as P2Y12 receptor antagonists in the treatment and/or prevention and/or treatment of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, including thrombosis in humans and other mammals. Formula (I).
Claims12
A compound of formula I
- wherein
- R1 represents phenyl optionally substituted 1 to 3 times by substituents each independently selected from the group consisting of halogen, methyl, methoxy, trifluoromethyl and trifluoromethoxy;
- R2 represents an alkoxyalkoxyalkyl group, a dihydroxyalkyl group, a dimethoxyalkyl group or a (2,2-dimethyl-[1,3]dioxolan-4-yl)-alkyl group;
- or R2 represents a group of the formula
- wherein
- either m is 1 and n is 2 or 3, or m is 2 and n is 2;
- and
- X represents O, S, NH, NR3, SO or SO2;
- R3 represents alkyl or arylalkyl;
- or also R2 represents 2,2,6,6-tetramethyl-piperidin-4-yl;
- each of R4 and R5 represents independently hydrogen or methyl;
- R6 represents alkoxy;
- and
- Y represents alkylene or phenylalkylene, and Z represents —OH, —COOH, cyano, tetrazolyl or —COOR7, R7 representing alkyl;
- or a salt of such a compound.
12 more elements
Dependencies are inferred from the claim text.