Biaryl ether urea compounds

A compound of Formula I

• wherein:
• each R1 is independently hydrogen, —OH, halogen, haloalkyl, —C1-C6alkyl, —O—C1-C6alkyl, —S—C1-C6alkyl, aryl, heteroaryl, —O-aryl, —O-heteroaryl, —NH2, —NHC(O)C1-C6alkyl, —(CH2)0-3—C3-C6cycloalkyl, —NHC(O)C3-C6cycloalkyl, —NHC1-C6alkyl, CN, —C(O)NR′R″ or —C(O)C1-C6alkyl;
• with each R1—C1-C6alkyl group being optionally substituted by an —O—C1-C6alkyl group or from 1 to 3 —OH substituents;
• R′ and R″ are independently selected from H or C1-C6alkyl;
• R2 is pyridazine;
• each R3 is independently hydrogen, halogen, haloalkyl, —C1-C6alkyl, —O—C1-C6alkyl, —S—C1-C6alkyl, —(CH2)0-3—C3-C6 cycloalkyl, —S—C3-C6cycloalkyl and —O—C3-C6cycloalkyl;
• said R3—C1-C6alkyl, —O—C1-C6alkyl, —S—C1-C6alkyl, —(CH2)0-3—C3-C6 cycloalkyl, —S—C3-C6cycloalkyl and —O—C3-C6cycloalkyl, groups are optionally substituted with from 1 to 4 halogen, haloalkyl, —O-haloalkyl, —C1-C6alkyl, or —O(C1-C6alkyl) substituents;
• R4 is hydrogen, —C1-C6alkyl, phenyl, —(CH2)0-3—C3-C6 cycloalkyl or halogen;
• said R4—C1-C6alkyl, phenyl, and —(CH2)0-3—C3-C6 cycloalkyl groups being optionally substituted with from 1 to 4 halogen, —C1-C6alkyl, or —O(C1-C6alkyl) substituents;
• X is N or CH;
• m is 0, 1, 2, 3, or 4;
• n is 0, 1, 2, 3 or 4;
• and
• Ar is aryl, —CH2-aryl, or heteroaryl, with said aryl, —CH2-aryl and heteroaryl groups being optionally independently substituted with from 1 to 4 substituents selected from hydrogen, —C1-C6alkyl, —C2-C6alkenyl, —C2-C6alkynyl, —(CH2)0-3—C3-C6 cycloalkyl, halogen, haloalkyl, —O-haloalkyl, —C(O)C1-C6alkyl, —O—C1-C6alkyl, —S—C1-C6alkyl, —O—C2-C6alkenyl, —O—C2-C6alkynyl, CN, aryl, heterocyclyl or heteroaryl;
• said —C1-C6alkyl, —(CH2)0-3—C3-C6cycloalkyl, —C(O)C1-C6alkyl, —O(C1-C6alkyl), —S—C1-C6alkyl, aryl, —CH2-aryl, heterocyclyl and heteroaryl substituents on Ar are optionally independently substituted with from 1 to 4 —C1-C6alkyl, —C1-C6alkoxy, —OH, or halogen substituents;
• or a pharmaceutically acceptable salt thereof.