Derivatives of sulindac, use thereof and preparation thereof
AssigneeSouthern Research Institute
InventorsGary Piazza, Robert Reynolds
Life of this patent
Estimating the term…
Abstract
Derivatives of sulindac are provided along with pharmaceutical compositions containing them and use for precancerous conditions and treating cancer. Derivatives of sulindac are also suitable for treating chronic inflammatory conditions. A method for preparing the derivatives is also provided.
Claims33
Compound selected from the group consisting of being N-[2-(dimethylamino)ethyl]-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetamide, 5-fluoro-2-methyl-N-[(1-methyl-2-pyrrolidinyl)ethyl]-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetamide, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-N-[2-(1-piperazinyl)ethyl]-1H-indene-3-acetamide, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-N-[2-(1-piperidinyl)ethyl]-1H-indene-3-acetamide, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-N-[2-(3-pyridinyl)ethyl]-1H-indene-3-acetamide, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-N-[2-(4-morpholinyl)ethyl]-1H-indene-3-acetamide, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-N-[2-(1-pyrrolidinyl)ethyl]-1H-indene-3-acetamide, N,2-dimethyl-N-[2-(dimethylamino)ethyl]-5-fluoro-1-[[4-ethylsulfinyl)phenyl]methylene]-1H-indene-3-acetamide, N-(2-aminoethyl)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetamide, N-[2-(dimethylamino)ethyl]-5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-1H-indene-3-acetamide, 5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-N-(phenylmethyl)-1H-indene-3-acetamide, 5-fluoro-N-(2-furanylmethyl)-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetamide, 5-fluoro-N-[2-(4-imidnzolyl)ethyl]-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene-1H-indene-3-acetamide, 5-fluoro-N-[2-(N,N-diethylamino)ethyl]-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene-1H-indene-3-acetamide, N-[[4-(dimethylamino)phenyl]methyl]-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetamide, ethanone, 2-[5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-inden-3-yl]-1-(4-methylpiperazinyl), N-[[4-(dimethylamino)phenyl]methyl]-(Z)-5-fluoro-2-methyl-3-[[4-(methylthio)phenyl]methylene]-1H-indene-3-acetamide, N,2-dimethyl-(Z)-5-fluoro-2-methyl-N[-2-(methylamino)ethyl]-[[4-(methylthio)phenyl]methylene]]-1H-indene-3-acetamide, N-[[4-(dimethylamino)phenyl]-(Z)-5-fluoro-2-methyl-3-[[4-(methylsulfinyl)phenyl]methylene]]-1H-indene-3-acetamide, N-[2-(dimethylamino)ethyl]-(Z)-5-fluoro-2-methyl-3-[[4-(methylsulfonyl)phenyl]methylene]]-1H-indene-3-acetamide, and N-[2-(dimethylamino)ethyl]-5-fluoro-2-methyl-1-[[4-(methylsulfide)phenyl]methylene]-1H-indene-3-acetamide,
- and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.