N-heterocyclic inhibitors of TNF-alpha expression
AssigneesBristol-Myers Squibb Company, Pharmacopeia, Inc.
InventorsGulzar Ahmed, Axel Metzger, Ian Henderson, David J. Diller, Jun Wen, Stephen T. Wrobleski, Katerina Leftheris, Chunjian Liu
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Abstract
N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula (I): Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-α expression utilizing compounds of the present invention are also disclosed.
Claims2
A compound or enantiomer, diastereomer, tautomer, or pharmaceutically acceptable salts thereof, wherein said compound is selected from:
Dependencies are inferred from the claim text.