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US 8,044,039 B2Granted
Quetiapine hemifumarate purification by crystallization
AssigneeFermion Oy
InventorsArne Grumann, Soini Huhta, Petteri Rummakko, Viesturs Lusis
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Abstract
The present invention relates to a process for preparing and purifying crystalline quetiapine hemifumarate, which comprises preparing crystalline quetiapine hemifumarate via a crystalline salt, which is not a salt of fumaric acid.
Claims12
A process for preparing crystalline quetiapine hemifumarate comprising the steps:
- a) crystallizing quetiapine first salt from a suitable solvent and;
- b) converting the first salt to quetiapine hemifumarate.
A process for crystallizing quetiapine hemifumarate comprising a) dissolving quetiapine base in a solvent;
- b) converting quetiapine to the first quetiapine salt;
- c) cooling the mixture to precipitate the first quetiapine salt;
- d) isolating the first quetiapine salt;
- and e) converting the first quetiapine salt to quetiapine hemifumarate.
1 more element
A process for purifying quetiapine hemifumarate comprising a) dissolving crude quetiapine hemifumarate in a solvent;
- b) optionally liberating quetiapine base from quetiapine hemifumarate;
- c) converting quetiapine to the first quetiapine salt;
- d) cooling the mixture to precipitate the first quetiapine salt;
- e) isolating the first quetiapine salt;
- and f) converting the first quetiapine salt to quetiapine hemifumarate.
2 more elements
Dependencies are inferred from the claim text.