Antibiotic macrocycle compounds and methods of manufacture and use thereof
AssigneeOptimer Pharmaceuticals, Inc.
InventorsYoshi Ichikawa, Yu-Hung Chiu, Youe-Kong Shue, Farah Kondori Babakhani
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Abstract
The invention encompasses an active metabolite of the 18-membered macrocyclic antimicrobial agents, specifically, a metabolite of tiacumicin B and in certain embodiments, R-Tiacumicin B or and its related compounds. In particular, the invention encompasses a compound that acts as a potent antibiotic agent for the treatment of bacterial infections, specifically GI infections caused by toxin producing strains of Clostridium difficile (C. difficile) and Clostridium perfringens (C. perfringens).
Claims20
A pharmaceutical composition comprising a compound of formula II
- in free form or in the form of its pharmaceutically acceptable salts.
A method for treating bacterial infections in a mammal, which comprises administering to said mammal a composition comprising a therapeutically or prophylactically effective amount of a compound of Formula II:
- in free form or in the form of its pharmaceutically acceptable salts.
A method for treating bacterial infections in a mammal, which comprises contacting the gastrointestinal tract of said mammal with a compound of Formula II:
- in free form or in the form of its pharmaceutically acceptable salts.
Dependencies are inferred from the claim text.