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US 8,044,024 B2Granted
Identifying modulators of fibroblast growth factor-like polypeptides
AssigneeAmgen Inc.
InventorsArlen Read Thomason, Benxian Liu
Life of this patent
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Abstract
The present invention provides novel Fibroblast Growth Factor-like (FGF-like) polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, antibodies and methods for producing FGF-like polypeptides. Also provided for are methods for the diagnosis and treatment of diseases associated with FGF-like polypeptides.
Claims10
A method of identifying a modulator of FGF-like polypeptide activity comprising:
- (a) incubating a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2, the amino acid sequence of SEQ ID NO:
- 5, or an amino acid sequence that is at least 95% identical to the amino acid sequence of either SEQ ID NO:
- 2 or SEQ ID NO:
- 5, with a test molecule, under conditions that permit interaction of the polypeptide with the test molecule;
- and
- (b) measuring FGF-like polypeptide activity to identify a test molecule that modulates FGF-like polypeptide activity.
4 more elements
A method of identifying a modulator of FGF-like polypeptide activity comprising:
- (a) transforming an isolated host cell with a vector comprising the nucleotide sequence of SEQ ID NO:
- 1, the DNA insert in ATCC Deposit No. PTA-626, or a nucleotide sequence that is 95% identical to the nucleotide sequence of either SEQ ID NO:
- 1 or the DNA insert in ATCC Deposit No. PTA-626;
- (b) incubating the host cell with a test molecule, under conditions that permit interaction of the polypeptide encoded by the nucleotide sequence of either SEQ ID NO:
- 1 or the DNA insert in ATCC Deposit No. PTA-626 with the test molecule;
- and
- (c) measuring FGF-like polypeptide activity to identify a test molecule that modulates FGF-like polypeptide activity.
4 more elements
Dependencies are inferred from the claim text.