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US 8,044,023 B2Granted
Hepatitis C virus inhibitors
AssigneeBristol-Myers Squibb Company
InventorsAlan Xiangdong Wang, Paul Michael Scola
Life of this patent
Estimating the term…
Abstract
Hepatitis C virus inhibitors having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
Claims20
A compound of formula (I)
- or a pharmaceutically acceptable salt thereof, wherein
- R2a and R2b are independently selected from hydrogen and methyl;
- R3 is selected from alkenyl, alkyl, aryl, arylalkyl, cycloalkyl, (cycloalkyl)alkyl, heterocyclyl, and heterocyclylalkyl;
- R4 is selected from —SR8, —S(O)—R8, and SO2R8;
- R6 is selected from hydrogen, alkoxycarbonyl, alkyl, alkylcarbonyl, alkylsulfonyl, cycloalkyloxycarbonyl, cycloalkyl, haloalkoxycarbonyl, haloalkyl, haloalkylcarbonyl, (NReRf)carbonyl, and (NReRf)sulfonyl;
- or
- R6 is selected from phenyl and a five- or six-membered partially or fully unsaturated ring optionally containing one, two, three, or four heteroatoms selected from nitrogen, oxygen, and sulfur;
- wherein each of the rings is optionally substituted with one, two, three, or four substituents independently selected from alkoxy, alkoxycarbonyl, alkyl, alkylcarbonyl, alkylsulfanyl, carboxy, cyano, cycloalkyl, cycloalkyloxy, halo, haloalkyl, haloalkoxy, —NRgRh, (NRjRk)carbonyl, (NRjRk)sulfonyl, and oxo;
- R7 is selected from alkyl, cycloalkyl, and (cycloalkyl)alkyl;
- wherein the cycloalkyl and the cycloalkyl part of the (cycloalkyl)alkyl are optionally substituted with one group selected from alkenyl, alkoxy, alkyl, and halo;
- R8 is selected from alkoxyalkyl, alkyl, arylalkyl, haloalkoxyalkyl, and haloalkyl;
- and
- Q is a C5-7 saturated or unsaturated chain.
10 more elements
A compound which is
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.