Infection and treatment of neoplasms with vesicular stomatitis virus
AssigneeWellstat Biologics Corporation
InventorsMichael S. Roberts, Robert M. Lorence, William S. Groene, Harvey Rabin, Reid W. von Borstel
Life of this patent
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Abstract
The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.
Claims58
A method of infecting a tumor with a volume of ≧300 mm3 in a mammal with a virus comprising systemically administering to said mammal an interferon-sensitive, replication-competent clonal vesicular stomatitis virus (VSV) derived from a single infectious virus particle and for which eight individual molecular clones from the population of virions have an identical sequence over 300 contiguous nucleotides, wherein said virus is administered as a first dose and one or more subsequent doses, and wherein the first dose is a desensitizing dose, to thereby infect said tumor.
A method of treating a tumor with a volume of ≧300 mm3 in a mammal comprising systemically administering to said mammal a therapeutically effective amount of an interferon-sensitive, replication-competent clonal vesicular stomatitis virus (VSV) derived from a single infectious virus particle and for which eight individual molecular clones from the population of virions have an identical sequence over 300 contiguous nucleotides, wherein said virus is administered as a first dose and one or more subsequent doses, and wherein the first dose is a desensitizing dose, to thereby treat said tumor.
A method of infecting a neoplasm in a mammal with a virus comprising systemically administering an interferon-sensitive, replication-competent clonal vesicular stomatitis virus (VSV) derived from a single infectious virus particle and for which eight individual molecular clones from the population of virions have an identical sequence over 300 contiguous nucleotides, wherein said virus is administered as a first dose and one or more subsequent doses, wherein the first dose is a desensitizing dose, and wherein said one or more subsequent doses are higher than the first dose.
A method of treating a tumor in a mammal comprising systemically administering to said mammal a therapeutically effective amount of an interferon-sensitive, replication-competent clonal vesicular stomatitis virus (VSV) derived from a single infectious virus particle and for which eight individual molecular clones from the population of virions have an identical sequence over 300 contiguous nucleotides, wherein said virus is administered as a first dose and one or more subsequent doses, wherein the first dose is a desensitizing dose and wherein said one or more subsequent doses are higher than the first dose, to thereby treat said tumor.
Dependencies are inferred from the claim text.