Naphthalene-based inhibitors of anti-apoptotic proteins
AssigneeBurnham Institute for Medical Research
InventorMaurizio Pellecchia
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Abstract
Methods of using apogossypol and its derivatives for treating inflammation is disclosed. Also, there is described a group of compounds having structure A, or a pharmaceutically acceptable salt, hydrate, N-oxide, or solvate thereof are provided: wherein each R is independently H, C(O)X, C(O)NHX, NH(CO)X, SO2NHX, or NHSO2X, wherein X is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, heterocycle, or substituted heterocycle. Compounds of group A may be used for treating various diseases or disorders, such as cancer.
Claims25
A compound having structure A, or a pharmaceutically acceptable salt thereof:
- wherein:
- each R is independently C(O)NHX;
- and
- X is (C1-C6)alkyl, substituted (C1-C6)alkyl, (C3-C8)cycloalkyl, substituted (C3-C8)cycloalkyl, aryl, substituted aryl, (C1-C6)alkylaryl, substituted (C1-C6)alkylaryl, wherein each X substituent is independently substituted or unsubstituted (C1-C6)alkyl, trifluoromethyl, halogen, substituted or unsubstituted phenyl or phenoxy.
Dependencies are inferred from the claim text.